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Appl. Sci. 2014, 4(3), 380-389; doi:10.3390/app4030380

Comparisons of Halogenated β-Nitrostyrenes as Antimicrobial Agents

Health Innovations Research Institute & School of Applied Sciences RMIT University, Melbourne, VIC 3001, Australia
Author to whom correspondence should be addressed.
Received: 7 July 2014 / Revised: 22 August 2014 / Accepted: 22 August 2014 / Published: 29 August 2014
(This article belongs to the Special Issue Feature Papers)
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The influence of three types of halogen-substituted E-β-methyl-β-nitrostyrenes (such as Compounds B, D, H) to overcome bacterial activity that is currently a significant health threat was studied. The evaluations of their bio-potency was measured and related to their structure and activity relationships for the purposes of serving to inhibit and overcoming resistant microorganisms. In particular, fluorine-containing β-nitrostyrenes were found to be highly active antimicrobial agents. The addition of the β-bromo group enhanced the antibacterial activity significantly. Our work has illustrated that halogen substituents at both the 4-position in the aromatic ring and also at the β-position on the alkene side chain of nitropropenyl arenes enhanced the antimicrobial activity of these compounds. View Full-Text
Keywords: antimicrobial agents; medicinal chemistry; halogenated β-methyl-β-nitrostyrenes; Minimum Inhibitory Concentration antimicrobial agents; medicinal chemistry; halogenated β-methyl-β-nitrostyrenes; Minimum Inhibitory Concentration

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Cornell, H.; Nguyen, T.; Nicoletti, G.; Jackson, N.; Hügel, H. Comparisons of Halogenated β-Nitrostyrenes as Antimicrobial Agents. Appl. Sci. 2014, 4, 380-389.

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