Comparisons of Halogenated β-Nitrostyrenes as Antimicrobial Agents
AbstractThe influence of three types of halogen-substituted E-β-methyl-β-nitrostyrenes (such as Compounds B, D, H) to overcome bacterial activity that is currently a significant health threat was studied. The evaluations of their bio-potency was measured and related to their structure and activity relationships for the purposes of serving to inhibit and overcoming resistant microorganisms. In particular, fluorine-containing β-nitrostyrenes were found to be highly active antimicrobial agents. The addition of the β-bromo group enhanced the antibacterial activity significantly. Our work has illustrated that halogen substituents at both the 4-position in the aromatic ring and also at the β-position on the alkene side chain of nitropropenyl arenes enhanced the antimicrobial activity of these compounds. View Full-Text
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Cornell, H.; Nguyen, T.; Nicoletti, G.; Jackson, N.; Hügel, H. Comparisons of Halogenated β-Nitrostyrenes as Antimicrobial Agents. Appl. Sci. 2014, 4, 380-389.
Cornell H, Nguyen T, Nicoletti G, Jackson N, Hügel H. Comparisons of Halogenated β-Nitrostyrenes as Antimicrobial Agents. Applied Sciences. 2014; 4(3):380-389.Chicago/Turabian Style
Cornell, Hugh; Nguyen, Thu; Nicoletti, Gina; Jackson, Neale; Hügel, Helmut. 2014. "Comparisons of Halogenated β-Nitrostyrenes as Antimicrobial Agents." Appl. Sci. 4, no. 3: 380-389.