Next Article in Journal
Acute Administration of Caffeine: The Effect on Motor Coordination, Higher Brain Cognitive Functions, and the Social Behavior of BLC57 Mice
Previous Article in Journal
PerLE: An “Open Source”, ELearning Moodle-Based, Platform. A Study of University Undergraduates’ Acceptance
Article Menu

Export Article

Open AccessArticle
Behav. Sci. 2018, 8(7), 64; https://doi.org/10.3390/bs8070064

Temporal Profiles and Dose-Responsiveness of Side Effects with Escitalopram and Duloxetine in Treatment-Naïve Depressed Adults

1
Emory University School of Medicine, Atlanta, GA 30322, USA
2
Department of Psychiatry and Behavioral Sciences, Mount Sinai School of Medicine, New York, NY 10029, USA
3
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30329, USA
4
Department of Psychology, Emory University, Atlanta, GA 30329, USA
5
Department of Psychiatry and Behavioral Sciences, Tulane University School of Medicine, New Orleans, LA 70112, USA
*
Author to whom correspondence should be addressed.
Received: 1 June 2018 / Revised: 10 July 2018 / Accepted: 16 July 2018 / Published: 17 July 2018
Full-Text   |   PDF [1640 KB, uploaded 17 July 2018]   |  
  |   Review Reports

Abstract

Side effect profiles of antidepressants are relevant to treatment selection and adherence among patients with major depressive disorder (MDD), but several clinically-relevant characteristics of side effects are poorly understood. We aimed to compare the side effect profiles of escitalopram and duloxetine, including frequencies, time to onset, duration, dose responsiveness, and impact on treatment outcomes. Side effects occurring in 211 treatment-naïve patients with MDD randomized to 12 weeks of treatment with flexibly-dosed escitalopram (10–20 mg/day) or duloxetine (30–60 mg/day) as part of the Predictors of Remission in Depression to Individual and Combined Treatments (PReDICT) study were evaluated. Escitalopram- and duloxetine-treated patients experienced a similar mean number of overall side effects and did not differ in terms of the specific side effects observed or their temporal profile. Experiencing any side effect during the first 2 weeks of treatment was associated with increased likelihood of trial completion (86.7% vs. 73.7%, p = 0.045). Duloxetine-treated patients who experienced dry mouth were significantly more likely to achieve remission than those who did not (73.7% vs. 44.8%, p = 0.026). Side effects that resolved prior to a dose increase were unlikely to recur after the increase, but only about 45% of intolerable side effects that required a dose reduction resolved within 30 days of the reduction. At the doses used in this study, escitalopram and duloxetine have similar side effect profiles. Understanding characteristics of side effects beyond simple frequency rates may help prescribers make more informed medication decisions and support conversations with patients to improve treatment adherence. View Full-Text
Keywords: adverse drug reaction; drug toxicity; antidepressant; serotonin uptake inhibitors; medication adherence adverse drug reaction; drug toxicity; antidepressant; serotonin uptake inhibitors; medication adherence
Figures

Figure 1a

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Supplementary material

SciFeed

Share & Cite This Article

MDPI and ACS Style

Polychroniou, P.E.; Mayberg, H.S.; Craighead, W.E.; Rakofsky, J.J.; Aponte Rivera, V.; Haroon, E.; Dunlop, B.W. Temporal Profiles and Dose-Responsiveness of Side Effects with Escitalopram and Duloxetine in Treatment-Naïve Depressed Adults. Behav. Sci. 2018, 8, 64.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Behav. Sci. EISSN 2076-328X Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top