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Behav. Sci. 2018, 8(2), 21; doi:10.3390/bs8020021

Follow-Up of Peripheral IL-1β and IL-6 and Relation with Apoptotic Death in Drug-Resistant Temporal Lobe Epilepsy Patients Submitted to Surgery

1
Immunochemical Department, International Center for Neurological Restoration, 25th Ave, Playa, 15805, PC 11300 Havana, Cuba
2
Clinical Neurophysiology Lab., International Center for Neurological Restoration, PC 11300 Havana, Cuba
3
Biology Faculty, University of Havana, PC 10400 Havana, Cuba
4
Morphological Laboratory, International Center for Neurological Restoration, PC 11300 Havana, Cuba
5
Unit of Medical Research in Neurological Diseases, Specialty Hospital, National Medical Center, XXI Century IMSS, PC 06720 Mexico City, Mexico
*
Author to whom correspondence should be addressed.
Received: 5 December 2017 / Revised: 24 January 2018 / Accepted: 30 January 2018 / Published: 5 February 2018
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Abstract

Increasing amounts of evidence support the role of inflammation in epilepsy. This study was done to evaluate serum follow-up of IL-1β and IL-6 levels, as well as their concentration in the neocortex, and the relationship of central inflammation with NF-κB and annexin V in drug-resistant temporal lobe epileptic (DRTLE) patients submitted to surgical treatment. Peripheral and central levels of IL-1β and IL-6were measured by ELISA in 10 DRTLE patients. The sera from patients were taken before surgery, and 12 and 24 months after surgical treatment. The neocortical expression of NF-κB was evaluated by western blotting and annexin V co-localization with synaptophysin by immunohistochemistry. The neocortical tissues from five patients who died by non-neurological causes were used as control. Decreased serum levels of IL-1 and IL-6 were observed after surgery; at this time, 70% of patients were seizure-free. No values of IL-1 and IL-6 were detected in neocortical control tissue, whereas cytokine levels were evidenced in DRTLE. Increased NF-κB neocortex expression was found and the positive annexin V neurons were more obvious in the DRTLE tissue, correlating with IL-6 levels. The follow-up study confirmed that the inflammatory alterations disappeared one year after surgery, when the majority of patients were seizure-free, and the apoptotic death process correlated with inflammation. View Full-Text
Keywords: drug-resistant temporal lobe epilepsy; inflammation; apoptosis; IL-1β; IL-6; NF-κB drug-resistant temporal lobe epilepsy; inflammation; apoptosis; IL-1β; IL-6; NF-κB
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Lorigados Pedre, L.; Morales Chacón, L.M.; Pavón Fuentes, N.; Robinson Agramonte, M.A.; Serrano Sánchez, T.; Cruz-Xenes, R.M.; Hung, M.-L.D.; Estupiñán Díaz, B.; Báez Martín, M.M.; Orozco-Suárez, S. Follow-Up of Peripheral IL-1β and IL-6 and Relation with Apoptotic Death in Drug-Resistant Temporal Lobe Epilepsy Patients Submitted to Surgery. Behav. Sci. 2018, 8, 21.

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