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Med. Sci. 2018, 6(2), 28; https://doi.org/10.3390/medsci6020028

Relationship between Response to PDE5 Inhibitors and Penile Duplex Doppler Ultrasound in Erectile Dysfunction

1
Department of Urology, Giresun University Faculty of Medicine, Giresun, Sağlık Uygulama ve Araştırma Hastanesi Nizamiye Mah. Mumcular Sok. No: 1/1, 1 nolu Sağlık Ocağı Arkası, Merkez, Giresun P.K. 28200, Turkey
2
Department of Radiology, Giresun University Faculty of Medicine, Giresun P.K. 28200, Turkey
*
Author to whom correspondence should be addressed.
Received: 22 January 2018 / Revised: 18 March 2018 / Accepted: 22 March 2018 / Published: 26 March 2018
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Abstract

The relationship between the results of penile duplex Doppler ultrasound (PDDU) and response to vardenafil was investigated in patients diagnosed with erectile dysfunction (ED). Data from 148 patients with ED were analyzed retrospectively. Patients who did not respond to therapy were classified in to Group I (n = 32), those who responded partially were classified into Group II (n = 40), and complete responders were classified into Group III (n = 76). Age, comorbidities, and vascular and penile pathologies were compared among the three groups. While diabetes mellitus (DM) and dyslipidemia positivity adversely affected the response to treatment, the presence of hypertension (HT), Peyronie’s disease and priapism increased the therapeutic response to the treatment (p < 0.05). Arterial insufficiency was present in 20 (30.3%), 25 (37.9%) and 21 (31.8%) of the patients in Group I, Group II and Group III, respectively (p = 0.001). Venous insufficiency was observed in three (14.3%) patients in Group I and in eight (85.7%) patients in Group III (p = 0.001). Arterial/venous insufficiency was seen in 9 (30%), 14 (46.7%) and 7 (23.3%) of the patients in Group I, Group II and Group III, respectively (p = 0.001). The response rate to treatment was highest in normal patients according to PDDU, followed by patients with venous insufficiency. In addition, it was found that DM decreased the response to treatment, whereas the response increased in cases with HT, priapism and Peyronie’s disease. View Full-Text
Keywords: comorbidities; erectile dysfunction; penile duplex Doppler ultrasound; penile pathology; phosphodiesterase type-5 inhibitors comorbidities; erectile dysfunction; penile duplex Doppler ultrasound; penile pathology; phosphodiesterase type-5 inhibitors
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Ogreden, E.; Oğuz, U.; Demirelli, E.; Tosun, A.; Yalçın, O. Relationship between Response to PDE5 Inhibitors and Penile Duplex Doppler Ultrasound in Erectile Dysfunction. Med. Sci. 2018, 6, 28.

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