Iron Profile and Glycaemic Control in Patients with Type 2 Diabetes Mellitus
Abstract
:1. Introduction
2. Materials and Methods
2.1. Inclusion Criteria
- Group I—Control group (n = 50), consisting of age- and sex-matched healthy subjects. They were free from any ailment which could affect the parameters under study. They were not on any medication, and were chosen from the general population.
- Group II—Diabetes mellitus type 2 patients with optimal glycaemic control (n = 50), disease duration less than 7 years and HbA1C) level less than 8%. They were on lifestyle modifications and oral hypoglycaemic drugs.
- Group III—Diabetes mellitus type 2 patients with suboptimal glycaemic control (n = 50), disease duration more than 7 years and HbA1C level more than 8%. They were on lifestyle modifications, oral hypoglycaemic drugs, insulin, or a combination of all three.
2.2. Exclusion Criteria
2.3. Methodology
2.4. Ethical Statement
2.5. Statistical Analysis
3. Results
4. Discussion
5. Conclusions
Acknowledgments
Author Contributions
Conflicts of Interest
References
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Parameter | Group I | p Value (I vs. II) | Group II | p Value (II vs. III) | Group III | p Value (I vs. III) |
---|---|---|---|---|---|---|
Number | 50 | - | 50 | - | 50 | - |
Male/Female | 35/15 | - | 36/14 | - | 35/15 | - |
Age* | 48.78 ± 1.647 | 0.2137 | 52.4 ± 1.377 | 0.9154 | 53.26 ± 1.517 | 0.959 |
Disease duration (years) | - | - | <7 | - | >7 | - |
FPG (mg/dL)* | 110.1 ± 2.231 | <0.0001 | 182 ± 8.947 | 0.9448 | 185.4 ± 9.131 | <0.0001 |
HbA1c (%)* | 6.58 ± 0.069 | 0.0001 | 7.21 ± 0.066 | 0.000 | 8.74 ± 0.103 | 0.0001 |
BMI (kg/m2)* | 25.15 ± 0.43 | 0.0007 | 27.33 ± 0.42 | 0.826 | 26.99 ± 0.37 | 0.0051 |
Parameter | Group I | p Value (I vs. II) | Group II | p Value (II vs. III) | Group III | p Value (I vs. III) |
---|---|---|---|---|---|---|
Serum iron (µg/dL) | 105.34 ± 3.5 | 0.9178 | 107.33 ± 3.45 | 0.0012 | 125.58 ± 3.74 | 0.0003 |
TIBC (µg/dL) | 311.39 ± 5.47 | 0.9674 | 309.63 ± 6.1 | 0.0015 | 284.2 ± 3.18 | 0.0006 |
Tsat (%) | 34.17 ± 1.21 | 0.8622 | 35.02 ± 1.2 | 0.0002 | 44.39 ± 1.07 | 0.0001 |
Parameter | Pearson Coefficient (r) | pValue |
---|---|---|
HbA1c | 0.05 | 0.73 |
Tsat | 0.0496 | 0.732 |
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Misra, G.; Bhatter, S.K.; Kumar, A.; Gupta, V.; Khan, M.Y. Iron Profile and Glycaemic Control in Patients with Type 2 Diabetes Mellitus. Med. Sci. 2016, 4, 22. https://doi.org/10.3390/medsci4040022
Misra G, Bhatter SK, Kumar A, Gupta V, Khan MY. Iron Profile and Glycaemic Control in Patients with Type 2 Diabetes Mellitus. Medical Sciences. 2016; 4(4):22. https://doi.org/10.3390/medsci4040022
Chicago/Turabian StyleMisra, Gunjan, Surendra Kumar Bhatter, Ajai Kumar, Varsha Gupta, and Mohd Y. Khan. 2016. "Iron Profile and Glycaemic Control in Patients with Type 2 Diabetes Mellitus" Medical Sciences 4, no. 4: 22. https://doi.org/10.3390/medsci4040022