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Animals 2015, 5(3), 793-802; doi:10.3390/ani5030384

The Role of TCA Cycle Anaplerosis in Ketosis and Fatty Liver in Periparturient Dairy Cows

Department of Dairy Science, University of Wisconsin-Madison, Madison, WI 53706, USA
Academic Editor: Àlex Bach
Received: 4 May 2015 / Revised: 26 July 2015 / Accepted: 6 August 2015 / Published: 18 August 2015
(This article belongs to the Special Issue Nutritional and Metabolic Health of Dairy Cow)
View Full-Text   |   Download PDF [341 KB, uploaded 18 August 2015]   |  

Abstract

The transition to lactation period in dairy cattle is characterized by metabolic challenges, negative energy balance, and adipose tissue mobilization. Metabolism of mobilized adipose tissue is part of the adaptive response to negative energy balance in dairy cattle; however, the capacity of the liver to completely oxidize nonesterified fatty acids may be limited and is reflective of oxaloacetate pool, the carbon carrier of the tricarboxylic acid cycle. Alternative metabolic fates of acetyl-CoA from nonesterified fatty acids include esterification to triacylglycerides and ketogenesis, and when excessive, these pathways lead to fatty liver and ketosis. Examination of the anaplerotic and cataplerotic pull of oxaloacetate by the tricarboxylic acid cycle and gluconeogenesis may provide insight into the balance of oxidation and esterification of acetyl-CoA within the liver of periparturient dairy cows. View Full-Text
Keywords: periparturient dairy cow; fatty liver; ketosis; anaplerosis; TCA cycle; fatty acid oxidation periparturient dairy cow; fatty liver; ketosis; anaplerosis; TCA cycle; fatty acid oxidation
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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White, H.M. The Role of TCA Cycle Anaplerosis in Ketosis and Fatty Liver in Periparturient Dairy Cows. Animals 2015, 5, 793-802.

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