Next Article in Journal
Relationships between Circulating Urea Concentrations and Endometrial Function in Postpartum Dairy Cows
Next Article in Special Issue
Lameness Detection in Dairy Cows: Part 1. How to Distinguish between Non-Lame and Lame Cows Based on Differences in Locomotion or Behavior
Previous Article in Journal
Physiologic Measures of Animal Stress during Transitional States of Consciousness
Previous Article in Special Issue
Measuring Claw Conformation in Cattle: Assessing the Agreement between Manual and Digital Measurement
Article Menu

Export Article

Open AccessArticle
Animals 2015, 5(3), 717-747; doi:10.3390/ani5030381

Alterations of Innate Immunity Reactants in Transition Dairy Cows before Clinical Signs of Lameness

Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, AB, T6G 2P5, Canada
*
Author to whom correspondence should be addressed.
Academic Editor: Jon Huxley
Received: 15 April 2015 / Revised: 9 July 2015 / Accepted: 4 August 2015 / Published: 14 August 2015
(This article belongs to the Special Issue Dairy Cow Mobility and Lameness)
View Full-Text   |   Download PDF [2047 KB, uploaded 14 August 2015]   |  

Simple Summary

Lameness is prevalent in dairy cows and early diagnosis and timely treatment of the disease can lower animal suffering, improve recovery rate, increase longevity, and minimize cow loss. However, there are no indications of disease until it appears clinically, and presently the only approach to deal with the sick cow is intensive treatment or culling. The results suggest that lameness affected serum concentrations of the several parameters related to innate immunity and carbohydrate metabolism that might be used to monitor health status of transition dairy cows in the near future.

Abstract

The objectives of this study were to evaluate metabolic and innate immunity alterations in the blood of transition dairy cows before, during, and after diagnosis of lameness during periparturient period. Blood samples were collected from the coccygeal vain once per week before morning feeding from 100 multiparous Holstein dairy cows during −8, −4, disease diagnosis, and +4 weeks (wks) relative to parturition. Six healthy cows (CON) and six cows that showed clinical signs of lameness were selected for intensive serum analyses. Concentrations of interleukin-1 (IL-1), interleukin-6 (IL-6), tumor necrosis factor (TNF), haptoglobin (Hp), serum amyloid A (SAA), lipopolysaccharide binding protein (LBP), lactate, non-esterified fatty acids (NEFA), and β-hydroxybutyrate (BHBA) were measured in serum by ELISA or colorimetric methods. Health status, DMI, rectal temperature, milk yield, and milk composition also were monitored for each cow during the whole experimental period. Results showed that cows affected by lameness had greater concentrations of lactate, IL-6, and SAA in the serum vs. CON cows. Concentrations of TNF tended to be greater in cows with lameness compared with CON. In addition, there was a health status (Hs) by time (week) interaction for IL-1, TNF, and Hp in lameness cows vs. CON ones. Enhanced serum concentrations of lactate, IL-6, and SAA at −8 and −4 wks before parturition were different in cows with lameness as compared with those of the CON group. The disease was also associated with lowered overall milk production and DMI as well as milk fat and fat-to-protein ratio. In conclusion, cows affected postpartum by lameness had alterations in several serum variables related to innate immunity and carbohydrate metabolism that give insights into the etiopathogenesis of the disease and might serve to monitor health status of transition dairy cows in the near future. View Full-Text
Keywords: dairy cow; blood; cytokines; acute phase proteins; metabolites; lameness dairy cow; blood; cytokines; acute phase proteins; metabolites; lameness
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Zhang, G.; Hailemariam, D.; Dervishi, E.; Deng, Q.; Goldansaz, S.A.; Dunn, S.M.; Ametaj, B.N. Alterations of Innate Immunity Reactants in Transition Dairy Cows before Clinical Signs of Lameness. Animals 2015, 5, 717-747.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Animals EISSN 2076-2615 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top