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Animals 2015, 5(2), 442-454; doi:10.3390/ani5020365

Dietary Mannoheptulose Increases Fasting Serum Glucagon Like Peptide-1 and Post-Prandial Serum Ghrelin Concentrations in Adult Beagle Dogs

1
Centre for Nutrition Modelling, Department of Animal and Poultry Science, University of Guelph, Guelph, ON N1G 2W1, Canada
2
The Iams Company, 6571 State Route 503 North, Lewisburg, OH 45338, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Adronie Verbrugghe
Received: 31 March 2015 / Accepted: 9 June 2015 / Published: 16 June 2015
(This article belongs to the Special Issue 'Freedom from Hunger' and Prevention of Obesity)
View Full-Text   |   Download PDF [171 KB, uploaded 16 June 2015]

Simple Summary

There is increased interest in the use of nutraceuticals for weight management in companion animals. A nutraceutical can broadly be considered a food (or a part of) that provides a health benefit. Mannoheptulose (MH), a sugar found in avocados, is being investigated as a nutraceutical for dogs. In this study, dogs fed a diet containing MH had increased concentrations of blood biomarkers related to energy intake. In addition, dogs fed MH were less physically active than dogs fed a control diet. These findings suggest that dietary MH has the ability to alter energy intake and lower daily energy expenditure.

Abstract

There is a growing interest in the use of nutraceuticals for weight management in companion animals. The purpose of this study was to determine the effects of mannoheptulose (MH), a sugar in avocados that inhibits glycolysis, on energy metabolism in adult Beagle dogs. The study was a double-blind, randomized controlled trial where dogs were allocated to a control (CON, n = 10, 10.1 ± 0.4 kg) or MH containing diet (168 mg/kg, n = 10, 10.3 ± 0.4 kg). Blood was collected after an overnight fast and 1 h post-feeding (week 12) to determine serum satiety related hormones and biochemistry. Resting and post-prandial energy expenditure and respiratory quotient were determined by indirect calorimetry (weeks 4 and 8). Physical activity was measured using an accelerometer (weeks 3, 7, 11). Body composition was assessed using dual X-ray absorptiometry (week 12). MH significantly (p < 0.05) increased fasting serum glucagon-like peptide-1 and post-prandial serum ghrelin. MH tended (p < 0.1) to increase fasting serum gastric inhibitory peptide and decrease physical activity. Together, these findings suggest that dietary MH has the ability to promote satiation and lowers daily energy expenditure. View Full-Text
Keywords: Beagle; body composition; dietary strategies; ghrelin; glucagon-like peptide-1; energy metabolism; indirect calorimetry; mannoheptulose; physical activity; satiety Beagle; body composition; dietary strategies; ghrelin; glucagon-like peptide-1; energy metabolism; indirect calorimetry; mannoheptulose; physical activity; satiety
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

McKnight, L.L.; Eyre, R.; Gooding, M.A.; Davenport, G.M.; Shoveller, A.K. Dietary Mannoheptulose Increases Fasting Serum Glucagon Like Peptide-1 and Post-Prandial Serum Ghrelin Concentrations in Adult Beagle Dogs. Animals 2015, 5, 442-454.

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