Next Article in Journal
Microbial Community and Potential Pathogen Shifts Along an Ornamental Fish Supply Chain
Previous Article in Journal
Influence of Season and Diet on Fiber Digestion and Bacterial Community Structure in the Rumen of Muskoxen (Ovibos moschatus)
Previous Article in Special Issue
The Interaction of the Gut Microbiota with the Mucus Barrier in Health and Disease in Human
Article Menu
Issue 3 (September) cover image

Export Article

Open AccessReview
Microorganisms 2018, 6(3), 90; https://doi.org/10.3390/microorganisms6030090

Dietary Nutrients, Proteomes, and Adhesion of Probiotic Lactobacilli to Mucin and Host Epithelial Cells

1
Department of Biotechnology, Bartin University, 74110 Bartin, Turkey
2
Department of Biotechnology and Biomedicine, Technical University of Denmark, DK-2800 Kgs Lyngby, Denmark
*
Author to whom correspondence should be addressed.
Received: 15 June 2018 / Revised: 13 August 2018 / Accepted: 14 August 2018 / Published: 21 August 2018
(This article belongs to the Special Issue Gut Bacteria-Mucus Interaction)
Full-Text   |   PDF [1203 KB, uploaded 21 August 2018]   |  

Abstract

The key role of diet and environment in human health receives increasing attention. Thus functional foods, probiotics, prebiotics, and synbiotics with beneficial effects on health and ability to prevent diseases are in focus. The efficacy of probiotic bacteria has been connected with their adherence to the host epithelium and residence in the gut. Several in vitro techniques are available for analyzing bacterial interactions with mucin and intestinal cells, simulating adhesion to the host in vivo. Proteomics has monitored and identified proteins of probiotic bacteria showing differential abundance elicited in vitro by exposure to food components, including potential prebiotics (e.g., certain carbohydrates, and plant polyphenols). While adhesion of probiotic bacteria influenced by various environmental factors relevant to the gastrointestinal tract has been measured previously, this was rarely correlated with changes in the bacterial proteome induced by dietary nutrients. The present mini-review deals with effects of selected emerging prebiotics, food components and ingredients on the adhesion of probiotic lactobacilli to mucin and gut epithelial cells and concomitant abundancy changes of specific bacterial proteins. Applying this in vitro synbiotics-like approach enabled identification of moonlighting and other surface-located proteins of Lactobacillus acidophilus NCFM that are possibly associated with the adhesive mechanism. View Full-Text
Keywords: lactobacilli; probiotics; adhesion; mucin; intestinal cells; carbon sources; polyphenols; surface proteomes; protein identification; moonlighting proteins lactobacilli; probiotics; adhesion; mucin; intestinal cells; carbon sources; polyphenols; surface proteomes; protein identification; moonlighting proteins
Figures

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Celebioglu, H.U.; Svensson, B. Dietary Nutrients, Proteomes, and Adhesion of Probiotic Lactobacilli to Mucin and Host Epithelial Cells. Microorganisms 2018, 6, 90.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Microorganisms EISSN 2076-2607 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top