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Microorganisms 2018, 6(3), 87; https://doi.org/10.3390/microorganisms6030087

Messing with the Sentinels—The Interaction of Staphylococcus aureus with Dendritic Cells

Department of Immunology, University Medicine Greifswald, Ferdinand-Sauerbruch-Straße DZ7, D-17475 Greifswald, Germany
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Received: 6 July 2018 / Revised: 12 August 2018 / Accepted: 14 August 2018 / Published: 15 August 2018
(This article belongs to the Special Issue Staphylococcus aureus Infection and Antimicrobial Resistance)
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Abstract

Staphylococcus aureus (S. aureus) is a dangerous pathogen as well as a frequent colonizer, threatening human health worldwide. Protection against S. aureus infection is challenging, as the bacteria have sophisticated strategies to escape the host immune response. To maintain equilibrium with S. aureus, both innate and adaptive immune effector mechanisms are required. Dendritic cells (DCs) are critical players at the interface between the two arms of the immune system, indispensable for inducing specific T cell responses. In this review, we highlight the importance of DCs in mounting innate as well as adaptive immune responses against S. aureus with emphasis on their role in S. aureus-induced respiratory diseases. We also review what is known about mechanisms that S. aureus has adopted to evade DCs or manipulate these cells to its advantage. View Full-Text
Keywords: S. aureus; dendritic cells; innate immunity; adaptive immunity; immune evasion; infection S. aureus; dendritic cells; innate immunity; adaptive immunity; immune evasion; infection
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Darisipudi, M.N.; Nordengrün, M.; Bröker, B.M.; Péton, V. Messing with the Sentinels—The Interaction of Staphylococcus aureus with Dendritic Cells. Microorganisms 2018, 6, 87.

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