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Reply published on 4 July 2017, see Microorganisms 2017, 5(3), 36.

Comment of Microorganisms 2017, 5(2), 22.

Open AccessComment
Microorganisms 2017, 5(2), 34; doi:10.3390/microorganisms5020034

Comment on: “Melanisation of Aspergillus terreus—Is Butyrolactone I Involved in the Regulation of Both DOPA and DHN Types of Pigments in Submerged Culture? Microorganisms 2017, 5, 22”

Fungal Genetics and Biology, School of Life Sciences, University of Nottingham, University Park, NG72RD Nottingham, UK
*
Author to whom correspondence should be addressed.
Received: 23 May 2017 / Revised: 9 June 2017 / Accepted: 19 June 2017 / Published: 21 June 2017
(This article belongs to the Special Issue Filamentous Fungi in White Biotechnology)
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Abstract

A recent article by Palonen et al. describes the effect of butyrolactone I on the expression of a secondary metabolite biosynthesis gene cluster from Aspergillus terreus that shows similarities to fusarubin biosynthesis gene clusters from Fusarium species. The authors claim that two different types of pigments are formed in Aspergillus terreus conidia, whereby one pigment is termed a DOPA-type melanin and the second a DHN-type melanin. Unfortunately, the terminology of the classification of melanin-types requires revision as Asp-melanin present in A. terreus conidia is clearly distinct from DOPA-melanins. In addition, some hypotheses in this manuscript are based on questionable data published previously, resulting in incorrect conclusions. Finally, as biochemical data are lacking and metabolite production is only deduced from bioinformatics and transcriptomic data, the production of a second pigment type in A. terreus conidia appears highly speculative. View Full-Text
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Geib, E.; Brock, M. Comment on: “Melanisation of Aspergillus terreus—Is Butyrolactone I Involved in the Regulation of Both DOPA and DHN Types of Pigments in Submerged Culture? Microorganisms 2017, 5, 22”. Microorganisms 2017, 5, 34.

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