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Microorganisms 2017, 5(1), 9; doi:10.3390/microorganisms5010009

Microbial Biofilms and Chronic Wounds

1
Innovotech Inc., Suite 101, 2011 94 Street, Edmonton, Alberta T6N 1H1, Canada
2
Harkynn Consulting, P.O. Box 104, Albertville, Saskatchewan S0J 0A0, Canada
3
Department of Obstetrics and Gynecology, Institute for Wound Research, University of Florida, 1600 South West Archer Road, Room M337F, Gainesville, FL 32610-0294, USA
4
Department of Biomedical Engineering, Faculties of Engineering and Medicine & Dentistry, 1101 Research Transition Facility, University of Alberta, Edmonton, Alberta T6G 2G6, Canada
*
Author to whom correspondence should be addressed.
Academic Editors: Gianfranco Donelli and Claudia Vuotto
Received: 17 January 2017 / Accepted: 4 March 2017 / Published: 7 March 2017
(This article belongs to the Special Issue Microbial Biofilms and Human Infections)
View Full-Text   |   Download PDF [618 KB, uploaded 8 March 2017]   |  

Abstract

Background is provided on biofilms, including their formation, tolerance mechanisms, structure, and morphology within the context of chronic wounds. The features of biofilms in chronic wounds are discussed in detail, as is the impact of biofilm on wound chronicity. Difficulties associated with the use of standard susceptibility tests (minimum inhibitory concentrations or MICs) to determine appropriate treatment regimens for, or develop new treatments for use in, chronic wounds are discussed, with alternate test methods specific to biofilms being recommended. Animal models appropriate for evaluating biofilm treatments are also described. Current and potential future therapies for treatment of biofilm-containing chronic wounds, including probiotic therapy, virulence attenuation, biofilm phenotype expression attenuation, immune response suppression, and aggressive debridement combined with antimicrobial dressings, are described. View Full-Text
Keywords: quorum sensing; antibiotic tolerance; antibiotic resistance; exopolymer; inflammation; wound healing; MBEC (minimum biofilm eradication concentration) quorum sensing; antibiotic tolerance; antibiotic resistance; exopolymer; inflammation; wound healing; MBEC (minimum biofilm eradication concentration)
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Omar, A.; Wright, J.B.; Schultz, G.; Burrell, R.; Nadworny, P. Microbial Biofilms and Chronic Wounds. Microorganisms 2017, 5, 9.

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