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Pathogens 2018, 7(3), 67; https://doi.org/10.3390/pathogens7030067

Impact of Mosquito Age and Insecticide Exposure on Susceptibility of Aedes albopictus (Diptera: Culicidae) to Infection with Zika Virus

Environmental Health Sciences Program, Department of Health Education and Promotion, College of Health and Human Performance, East Carolina University, Greenville, NC 27858, USA knechth16@students.ecu.edu (H.K.)
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Received: 10 July 2018 / Revised: 2 August 2018 / Accepted: 9 August 2018 / Published: 12 August 2018
(This article belongs to the Special Issue Virus-Host Interactions of Zika Virus)
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Abstract

Zika virus (ZIKV) is primarily transmitted to humans by Aedes aegypti and Ae. albopictus. Vector–virus interactions influencing vector competence vary and depend on biological and environmental factors. A mosquito’s chronological age may impact its immune response against virus infection. Insecticides, source reduction, and/or public education are currently the best defense against mosquitoes that transmit ZIKV. This study assessed the effects of a mosquito’s chronological age at time of infection on its response to ZIKV infection. We exposed young (6–7 d post-emergence) and old (11–12 d post-emergence) Ae. albopictus to a sublethal dose of bifenthrin prior to oral exposure to blood meals containing ZIKV (7-day incubation period). Old mosquitoes experienced a significantly (p < 0.01) higher rate of mortality than young mosquitoes. Significantly higher ZIKV body titers (p < 0.01) were observed in the old control group compared to the young control group. Significantly higher (p < 0.01) ZIKV dissemination rates and leg titers (p < 0.01) were observed in old bifenthrin-exposed mosquitoes compared to old control mosquitoes or young bifenthrin-exposed or control mosquitoes. Hence, bifenthrin exposure may increase the potential for virus transmission; however, the degree of these impacts varies with mosquito age. Impacts of insecticides should be considered in risk assessments of potential vector populations. View Full-Text
Keywords: vector competence; mosquito age; Zika; insecticides vector competence; mosquito age; Zika; insecticides
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Knecht, H.; Richards, S.L.; Balanay, J.A.G.; White, A.V. Impact of Mosquito Age and Insecticide Exposure on Susceptibility of Aedes albopictus (Diptera: Culicidae) to Infection with Zika Virus. Pathogens 2018, 7, 67.

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