Next Article in Journal
Acknowledgement to Reviewers of Pathogens in 2016
Next Article in Special Issue
Neurotrophic Factors NGF, GDNF and NTN Selectively Modulate HSV1 and HSV2 Lytic Infection and Reactivation in Primary Adult Sensory and Autonomic Neurons
Previous Article in Journal
Detection of Campylobacter jejuni in Lizard Faeces from Central Australia Using Quantitative PCR
Previous Article in Special Issue
Varicella-Zoster Virus Infectious Cycle: ER Stress, Autophagic Flux, and Amphisome-Mediated Trafficking
Article Menu

Export Article

Open AccessReview
Pathogens 2017, 6(1), 2; doi:10.3390/pathogens6010002

Herpesviruses dUTPases: A New Family of Pathogen-Associated Molecular Pattern (PAMP) Proteins with Implications for Human Disease

1
Department of Cancer Biology and Genetics, Wexner Medical Center, Ohio State University, Columbus, OH 43210, USA
2
Institute for Behavioral Medicine Research, Ohio State University, Columbus, OH 43210, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Angus Wilson
Received: 16 December 2016 / Revised: 16 December 2016 / Accepted: 21 December 2016 / Published: 28 December 2016
(This article belongs to the Special Issue Herpesviruses)
View Full-Text   |   Download PDF [1500 KB, uploaded 28 December 2016]   |  

Abstract

The human herpesviruses are ubiquitous viruses and have a prevalence of over 90% in the adult population. Following a primary infection they establish latency and can be reactivated over a person’s lifetime. While it is well accepted that human herpesviruses are implicated in numerous diseases ranging from dermatological and autoimmune disease to cancer, the role of lytic proteins in the pathophysiology of herpesvirus-associated diseases remains largely understudies. Only recently have we begun to appreciate the importance of lytic proteins produced during reactivation of the virus, in particular the deoxyuridine triphosphate nucleotidohydrolases (dUTPase), as key modulators of the host innate and adaptive immune responses. In this review, we provide evidence from animal and human studies of the Epstein–Barr virus as a prototype, supporting the notion that herpesviruses dUTPases are a family of proteins with unique immunoregulatory functions that can alter the inflammatory microenvironment and thus exacerbate the immune pathology of herpesvirus-related diseases including myalgic encephalomyelitis/chronic fatigue syndrome, autoimmune diseases, and cancer. View Full-Text
Keywords: herpesviruses; Epstein–Barr virus; deoxyuridine triphosphate nucleotidohydrolase; Toll-like receptor 2; myalgic encephalomyelitis/chronic fatigue syndrome; autoimmune diseases; lupus nephritis; cancer herpesviruses; Epstein–Barr virus; deoxyuridine triphosphate nucleotidohydrolase; Toll-like receptor 2; myalgic encephalomyelitis/chronic fatigue syndrome; autoimmune diseases; lupus nephritis; cancer
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Williams, M.V.; Cox, B.; Ariza, M.E. Herpesviruses dUTPases: A New Family of Pathogen-Associated Molecular Pattern (PAMP) Proteins with Implications for Human Disease. Pathogens 2017, 6, 2.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Pathogens EISSN 2076-0817 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top