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Pathogens 2015, 4(4), 793-815; doi:10.3390/pathogens4040793

Immunomodulation and Disease Tolerance to Staphylococcus aureus

Microbiome and Disease Tolerance Center, Department of Microbiology and Immunology, McGill University, Montréal, QC, H3A 2B4, Canada
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Author to whom correspondence should be addressed.
Academic Editor: Rachel McLoughlin
Received: 10 November 2015 / Accepted: 10 November 2015 / Published: 13 November 2015
(This article belongs to the Special Issue Staphylococcus Aureus Infection)
View Full-Text   |   Download PDF [542 KB, uploaded 16 November 2015]   |  

Abstract

The Gram-positive bacterium Staphylococcus aureus is one of the most frequent pathogens that causes severe morbidity and mortality throughout the world. S. aureus can infect skin and soft tissues or become invasive leading to diseases such as pneumonia, endocarditis, sepsis or toxic shock syndrome. In contrast, S. aureus is also a common commensal microbe and is often part of the human nasal microbiome without causing any apparent disease. In this review, we explore the immunomodulation and disease tolerance mechanisms that promote commensalism to S. aureus. View Full-Text
Keywords: Staphylococcus aureus; immunomodulation; disease tolerance; microbiome; interleukin-10 Staphylococcus aureus; immunomodulation; disease tolerance; microbiome; interleukin-10
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Li, Z.; Peres, A.G.; Damian, A.C.; Madrenas, J. Immunomodulation and Disease Tolerance to Staphylococcus aureus. Pathogens 2015, 4, 793-815.

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