Next Article in Journal
Molecular Detection and Characterization of Theileria Infecting Wildebeest (Connochaetes taurinus) in the Maasai Mara National Reserve, Kenya
Previous Article in Journal
Interleukin 17-Mediated Host Defense against Candida albicans
Article Menu

Export Article

Open AccessArticle
Pathogens 2015, 4(3), 620-625; doi:10.3390/pathogens4030620

In Vitro Activity of Cefepime/AAI101 and Comparators against Cefepime Non-susceptible Enterobacteriaceae

1
Center for Anti-Infective Research and Development, Hartford Hospital, 80 Seymour Street, Hartford, CT 06102, USA
2
Division of Infectious Diseases, Hartford Hospital, Hartford, CT 06102, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Lawrence S. Young
Received: 7 July 2015 / Revised: 30 July 2015 / Accepted: 12 August 2015 / Published: 18 August 2015
View Full-Text   |   Download PDF [182 KB, uploaded 18 August 2015]   |  

Abstract

We evaluated the in vitro potency of cefepime combined with AAI101, a novel extended-spectrum β-lactamase inhibitor, against a population of clinical Escherichia coli and Klebsiella pneumoniae collected from USA hospitals. Of the 223 cefepime non-susceptible isolates, 95% were ceftazidime non-susceptible, 49% ertapenem non-susceptible, 57% piperacillin/tazobactam non-susceptible, 90% were multidrug-resistant (resistant to ≥3 drug classes), 22% produced carbapenemases, and 67% produced ESBLs. Addition of AAI101 restored the activity of cefepime such that the MIC50 was reduced from >64 mg/L for cefepime to 0.13 mg/L for cefepime/AAI101, supporting its continued development treatment for infections caused by these organisms. View Full-Text
Keywords: Escherichia coli; Klebsiella pneumonia; ESBL; carbapenemase; β-lactamase inhibitor Escherichia coli; Klebsiella pneumonia; ESBL; carbapenemase; β-lactamase inhibitor
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Crandon, J.L.; Nicolau, D.P. In Vitro Activity of Cefepime/AAI101 and Comparators against Cefepime Non-susceptible Enterobacteriaceae. Pathogens 2015, 4, 620-625.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Pathogens EISSN 2076-0817 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top