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Metals 2016, 6(12), 309; doi:10.3390/met6120309

Effect of Immersion in Simulated Body Fluid on the Mechanical Properties and Biocompatibility of Sintered Fe–Mn-Based Alloys

Department of Chemical and Materials Engineering, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand
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Academic Editor: Ian Baker
Received: 17 August 2016 / Revised: 8 November 2016 / Accepted: 30 November 2016 / Published: 7 December 2016
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Abstract

Fe–Mn-based degradable biomaterials (DBMs) are promising candidates for temporary implants such as cardiovascular stents and bone fixation devices. Identifying their mechanical properties and biocompatibility is essential to determine the feasibility of Fe–Mn-based alloys as DBMs. This study presents the tensile properties of two powder metallurgical processed Fe–Mn-based alloys (Fe–28Mn and Fe–28Mn-3Si, in mass percent) as a function of immersion time in simulated body fluid (SBF). In addition, short-term cytotoxicity testing was performed to evaluate the in vitro biocompatibility of the sintered Fe–Mn-based alloys. The results reveal that an increase in immersion duration deteriorated the tensile properties of both the binary and ternary alloys. The tensile properties of the immersed alloys were severely degraded after being soaked in SBF for ≥45 days. The ion concentration in SBF released from the Fe–28Mn-3Si samples was higher than their Fe–28Mn counterparts after 7 days immersion. The preliminary cytotoxicity testing based on the immersed SBF medium after 7 days immersion suggested that both the Fe–28Mn-3Si and Fe–28Mn alloys presented a good biocompatibility in Murine fibroblast cells. View Full-Text
Keywords: Fe–Mn-based alloys; powder sintering; tensile properties; immersion; biocompatibility Fe–Mn-based alloys; powder sintering; tensile properties; immersion; biocompatibility
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Xu, Z.; Hodgson, M.A.; Cao, P. Effect of Immersion in Simulated Body Fluid on the Mechanical Properties and Biocompatibility of Sintered Fe–Mn-Based Alloys. Metals 2016, 6, 309.

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