Switch-Like Roles for Polycomb Proteins from Neurodevelopment to Neurodegeneration
AbstractPolycomb Group (PcG) proteins are best-known for maintaining repressive or active chromatin states that are passed on across multiple cell divisions, and thus sustain long-term memory of gene expression. PcG proteins engage different, partly gene- and/or stage-specific, mechanisms to mediate spatiotemporal gene expression during central nervous system development. In the course of this, PcG proteins bind to various cis-regulatory sequences (e.g., promoters, enhancers or silencers) and coordinate, as well the interactions between distantly separated genomic regions to control chromatin function at different scales ranging from compaction of the linear chromatin to the formation of topological hubs. Recent findings show that PcG proteins are involved in switch-like changes in gene expression states of selected neural genes during the transition from multipotent to differentiating cells, and then to mature neurons. Beyond neurodevelopment, PcG proteins sustain mature neuronal function and viability, and prevent progressive neurodegeneration in mice. In support of this view, neuropathological findings from human neurodegenerative diseases point to altered PcG functions. Overall, improved insight into the multiplicity of PcG functions may advance our understanding of human neurodegenerative diseases and ultimately pave the way to new therapies. View Full-Text
Scifeed alert for new publicationsNever miss any articles matching your research from any publisher
- Get alerts for new papers matching your research
- Find out the new papers from selected authors
- Updated daily for 49'000+ journals and 6000+ publishers
- Define your Scifeed now
Hoffmann, A.; Sportelli, V.; Ziller, M.; Spengler, D. Switch-Like Roles for Polycomb Proteins from Neurodevelopment to Neurodegeneration. Epigenomes 2017, 1, 21.
Hoffmann A, Sportelli V, Ziller M, Spengler D. Switch-Like Roles for Polycomb Proteins from Neurodevelopment to Neurodegeneration. Epigenomes. 2017; 1(3):21.Chicago/Turabian Style
Hoffmann, Anke; Sportelli, Vincenza; Ziller, Michael; Spengler, Dietmar. 2017. "Switch-Like Roles for Polycomb Proteins from Neurodevelopment to Neurodegeneration." Epigenomes 1, no. 3: 21.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.