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J. Pers. Med. 2016, 6(1), 10; doi:10.3390/jpm6010010

The Translational Genomics Core at Partners Personalized Medicine: Facilitating the Transition of Research towards Personalized Medicine

1
Partners HealthCare Personalized Medicine, 65 Landsdowne Street, Cambridge, MA 02139, USA
2
Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Scott T. Weiss
Received: 21 October 2015 / Revised: 4 February 2016 / Accepted: 18 February 2016 / Published: 26 February 2016
(This article belongs to the Special Issue Implementing Personalized Medicine in a Large Health Care System)
View Full-Text   |   Download PDF [761 KB, uploaded 26 February 2016]   |  

Abstract

The Translational Genomics Core (TGC) at Partners Personalized Medicine (PPM) serves as a fee-for-service core laboratory for Partners Healthcare researchers, providing access to technology platforms and analysis pipelines for genomic, transcriptomic, and epigenomic research projects. The interaction of the TGC with various components of PPM provides it with a unique infrastructure that allows for greater IT and bioinformatics opportunities, such as sample tracking and data analysis. The following article describes some of the unique opportunities available to an academic research core operating within PPM, such the ability to develop analysis pipelines with a dedicated bioinformatics team and maintain a flexible Laboratory Information Management System (LIMS) with the support of an internal IT team, as well as the operational challenges encountered to respond to emerging technologies, diverse investigator needs, and high staff turnover. In addition, the implementation and operational role of the TGC in the Partners Biobank genotyping project of over 25,000 samples is presented as an example of core activities working with other components of PPM. View Full-Text
Keywords: translational genomics core; academic core facility; genomics services; genotyping; seamless workflows translational genomics core; academic core facility; genomics services; genotyping; seamless workflows
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Blau, A.; Brown, A.; Mahanta, L.; Amr, S.S. The Translational Genomics Core at Partners Personalized Medicine: Facilitating the Transition of Research towards Personalized Medicine. J. Pers. Med. 2016, 6, 10.

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