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Open Access Integrated Therapeutic and Diagnostic Platforms for Personalized Cardiovascular Medicine
Theranostics Laboratory Ltd, North Shore Hospital, Private Bag 93503, Auckland 0622, New Zealand
Waitemata District Health Board, North Shore Hospital, Private Bag 93503, Auckland 0622, New Zealand
Auckland Bioengineering Institute, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand
Institute for Lasers, Photonics and Biophotonics, 428 Natural Science Complex, University at Buffalo, NY 14260-3000, USA
Ocean NanoTech, 2143 Worth Lane, Springdale, AR 72764, USA
Wyle Science, Technology and Engineering Group, 1200 Hercules, Houston, TX 77058, USA
DNA Medicine Institute, 727 Massachusetts Avenue, Cambridge, MA 02139, USA
Jet Propulsion Laboratory, California Institute of Technology, 4800 Oak Grove Dr, Pasadena, CA 91109, USA
NASA Glenn Research Center, 21000 Brookpark Rd, Cleveland, OH 44135, USA
National Space Biomedical Research Institute, 6500 Main Street, Suite 910, Houston, TX 77030-1402, USA
NASA Johnson Space Center, 2101 NASA Pkwy, Houston, TX 77058, USA
* Author to whom correspondence should be addressed.
Received: 22 June 2013; in revised form: 4 August 2013 / Accepted: 10 August 2013 / Published: 21 August 2013
Abstract: It is undeniable that the increasing costs in healthcare are a concern. Although technological advancements have been made in healthcare systems, the return on investment made by governments and payers has been poor. The current model of care is unsustainable and is due for an upgrade. In developed nations, a law of diminishing returns has been noted in population health standards, whilst in the developing world, westernized chronic illnesses, such as diabetes and cardiovascular disease have become emerging problems. The reasons for these trends are complex, multifactorial and not easily reversed. Personalized medicine has the potential to have a significant impact on these issues, but for it to be truly successful, interdisciplinary mass collaboration is required. We propose here a vision for open-access advanced analytics for personalized cardiac diagnostics using imaging, electrocardiography and genomics.
Keywords: pharmacogenomics; echocardiography; electrocardiography; personalized medicine; genomics
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Gladding, P.A.; Cave, A.; Zareian, M.; Smith, K.; Hussan, J.; Hunter, P.; Erogbogbo, F.; Aguilar, Z.; Martin, D.S.; Chan, E.; Homer, M.L.; Shevade, A.V.; Kassemi, M.; Thomas, J.D.; Schlegel, T.T. Open Access Integrated Therapeutic and Diagnostic Platforms for Personalized Cardiovascular Medicine. J. Pers. Med. 2013, 3, 203-237.
Gladding PA, Cave A, Zareian M, Smith K, Hussan J, Hunter P, Erogbogbo F, Aguilar Z, Martin DS, Chan E, Homer ML, Shevade AV, Kassemi M, Thomas JD, Schlegel TT. Open Access Integrated Therapeutic and Diagnostic Platforms for Personalized Cardiovascular Medicine. Journal of Personalized Medicine. 2013; 3(3):203-237.
Gladding, Patrick A.; Cave, Andrew; Zareian, Mehran; Smith, Kevin; Hussan, Jagir; Hunter, Peter; Erogbogbo, Folarin; Aguilar, Zoraida; Martin, David S.; Chan, Eugene; Homer, Margie L.; Shevade, Abhijit V.; Kassemi, Mohammad; Thomas, James D.; Schlegel, Todd T. 2013. "Open Access Integrated Therapeutic and Diagnostic Platforms for Personalized Cardiovascular Medicine." J. Pers. Med. 3, no. 3: 203-237.