Next Article in Journal
Single Domain Antibodies as New Biomarker Detectors
Next Article in Special Issue
Reporting and Handling of Indeterminate Bone Scan Results in the Staging of Prostate Cancer: A Systematic Review
Previous Article in Journal
Implementing a Multidisciplinary Tumor Board in the Community Practice Setting
Article Menu
Issue 4 (December) cover image

Export Article

Open AccessArticle
Diagnostics 2017, 7(4), 56; https://doi.org/10.3390/diagnostics7040056

Prospective Comparison of F-18 Choline PET/CT Scan Versus Axial MRI for Detecting Bone Metastasis in Biochemically Relapsed Prostate Cancer Patients

1
Department of Radiology, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium
2
Department of Radiology, Centre du Cancer and Institut de Recherche Expérimentale et Clinique, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Avenue Hippocrate 10/2942, B-1200 Brussels, Belgium
3
Service of Nuclear Medicine, Policlinico Sant’Orsola-Malpighi, University of Bologna, 40126 Bologna, Italy
4
Department of Radiation Oncology and Experimental Cancer Research, Ghent University, De Pintelaan 185, 9000 Ghent, Belgium
5
Nuclear Medicine, Institut Jules Bordet, Waterloolaan 121, 1000 Brussels, Belgium
6
Department of Nuclear Medicine, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium
7
Laboratory of Radiopharmacy, Faculty of Pharmaceutical Sciences, Ghent University, Ottergemsesteenweg 460, 9000 Ghent, Belgium
8
Radiology and Nuclear Medicine, Ghent University, De Pintelaan 185, 9000 Ghent, Belgium
9
Department of Radiation Oncology and Experimental Cancer Research, UZ Leuven, Herestraat 49, 3000 Leuven, Belgium
10
Department of Urology and Experimental Cancer Research, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium
11
Algemeen ziekenhuis Maria Middelares, Buitenring Sint-Denijs 30, 9000 Ghent, Belgium
*
Author to whom correspondence should be addressed.
Received: 22 September 2017 / Revised: 9 October 2017 / Accepted: 14 October 2017 / Published: 17 October 2017
(This article belongs to the Special Issue Imaging of Bone Metastases in Oncology)
View Full-Text   |   Download PDF [433 KB, uploaded 18 October 2017]   |  

Abstract

We compared fluor-18 choline positron emission tomography/computed tomography (PET/CT) and axial skeleton magnetic resonance imaging (MRI) prospectively obtained for the detection of bone metastases in non-castrated patients with biochemically recurrent prostate cancer following primary treatment. PET/CT was performed 45 min post-injection of 3–4 MBq/kg F-18 methyl choline. MRI included T1- and fluid sensitive T2-weighted images of the spine and pelvis. Readers were initially blinded from other results and all scans underwent independent double reading. The best valuable comparator (BVC) defined the metastatic status. On the basis of the BVC, 15 out of 64 patients presented with 24 bone metastases. On a patient level, the sensitivity and specificity of MRI and PET were not significantly different. On a lesion level, the sensitivity of MRI was significantly better compared to PET, and the specificity did not differ significantly. In conclusion, axial MRI is an interesting screening tool for the detection of bone metastases because of its low probability of false negative results. However, F-18 choline PET is a valuable addition as it can overrule false positive MRI results and detect non-axial metastases. View Full-Text
Keywords: choline PET/CT; MRI; bone metastasis; prostate cancer choline PET/CT; MRI; bone metastasis; prostate cancer
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Supplementary material

SciFeed

Share & Cite This Article

MDPI and ACS Style

Huysse, W.; Lecouvet, F.; Castellucci, P.; Ost, P.; Lambrecht, V.; Artigas, C.; Denis, M.-L.; Man, K.D.; Delrue, L.; Jans, L.; Bruycker, A.D.; Vos, F.D.; Meerleer, G.D.; Decaestecker, K.; Fonteyne, V.; Lambert, B. Prospective Comparison of F-18 Choline PET/CT Scan Versus Axial MRI for Detecting Bone Metastasis in Biochemically Relapsed Prostate Cancer Patients. Diagnostics 2017, 7, 56.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Diagnostics EISSN 2075-4418 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top