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Diagnostics 2016, 6(2), 21; doi:10.3390/diagnostics6020021

Limitations and Prospects for Diffusion-Weighted MRI of the Prostate

1
Discipline of Medical Radiation Sciences, Faculty of Health Sciences, University of Sydney, Sydney, NSW 2006, Australia
2
Centre for Medical Image Computing, University College London, London WC1E 6BT, UK
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Andreas Kjaer
Received: 29 April 2016 / Revised: 23 May 2016 / Accepted: 23 May 2016 / Published: 27 May 2016
(This article belongs to the Special Issue Prostate Cancer Diagnosis)
View Full-Text   |   Download PDF [243 KB, uploaded 27 May 2016]

Abstract

Diffusion-weighted imaging (DWI) is the most effective component of the modern multi-parametric magnetic resonance imaging (mpMRI) scan for prostate pathology. DWI provides the strongest prediction of cancer volume, and the apparent diffusion coefficient (ADC) correlates moderately with Gleason grade. Notwithstanding the demonstrated cancer assessment value of DWI, the standard measurement and signal analysis methods are based on a model of water diffusion dynamics that is well known to be invalid in human tissue. This review describes the biophysical limitations of the DWI component of the current standard mpMRI protocol and the potential for significantly improved cancer assessment performance based on more sophisticated measurement and signal modeling techniques. View Full-Text
Keywords: prostate; cancer; MRI; mpMRI; diffusion; microstructure; modeling prostate; cancer; MRI; mpMRI; diffusion; microstructure; modeling
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Bourne, R.; Panagiotaki, E. Limitations and Prospects for Diffusion-Weighted MRI of the Prostate. Diagnostics 2016, 6, 21.

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