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Natriuretic Peptides in Kawasaki Disease: the Myocardial Perspective
Division of Pediatric Cardiology, CHU Ste-Justine, University of Montreal, Montreal, QC H3T 1C5, Canada
* Author to whom correspondence should be addressed.
Received: 5 December 2012; in revised form: 20 December 2012 / Accepted: 31 December 2012 / Published: 10 January 2013
Abstract: Making a diagnosis of Kawasaki disease with certainty may be challenging, especially since the recognition of cases with incomplete diagnostic criteria and its consequences. In order to build the diagnostic case in daily practice, clinicians rely on clinical criteria established over four decades ago, aided by non specific laboratory tests, and above all inspired by experience. We have recently studied the diagnostic value of N-terminal pro B-type natriuretic peptide to improve the diagnostic certainty of cases with complete or incomplete clinical criteria. Our working hypothesis was based on the fact that myocarditis is present in nearly all Kawasaki disease patients supported by histology data. In this paper, we review these facts and the myocardial perspective from the diagnostic and the mechanistic standpoints.
Keywords: Kawasaki disease; myocarditis; NT-proBNP; hyponatremia; diagnosis; prognosis
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Cite This Article
MDPI and ACS Style
Dahdah, N.; Fournier, A. Natriuretic Peptides in Kawasaki Disease: the Myocardial Perspective. Diagnostics 2013, 3, 1-12.
Dahdah N, Fournier A. Natriuretic Peptides in Kawasaki Disease: the Myocardial Perspective. Diagnostics. 2013; 3(1):1-12.
Dahdah, Nagib; Fournier, Anne. 2013. "Natriuretic Peptides in Kawasaki Disease: the Myocardial Perspective." Diagnostics 3, no. 1: 1-12.