Efforts and Challenges in Engineering the Genetic Code
AbstractThis year marks the 48th anniversary of Francis Crick’s seminal work on the origin of the genetic code, in which he first proposed the “frozen accident” hypothesis to describe evolutionary selection against changes to the genetic code that cause devastating global proteome modification. However, numerous efforts have demonstrated the viability of both natural and artificial genetic code variations. Recent advances in genetic engineering allow the creation of synthetic organisms that incorporate noncanonical, or even unnatural, amino acids into the proteome. Currently, successful genetic code engineering is mainly achieved by creating orthogonal aminoacyl-tRNA/synthetase pairs to repurpose stop and rare codons or to induce quadruplet codons. In this review, we summarize the current progress in genetic code engineering and discuss the challenges, current understanding, and future perspectives regarding genetic code modification. View Full-Text
Scifeed alert for new publicationsNever miss any articles matching your research from any publisher
- Get alerts for new papers matching your research
- Find out the new papers from selected authors
- Updated daily for 49'000+ journals and 6000+ publishers
- Define your Scifeed now
Lin, X.; Yu, A.C.S.; Chan, T.F. Efforts and Challenges in Engineering the Genetic Code. Life 2017, 7, 12.
Lin X, Yu ACS, Chan TF. Efforts and Challenges in Engineering the Genetic Code. Life. 2017; 7(1):12.Chicago/Turabian Style
Lin, Xiao; Yu, Allen Chi Shing; Chan, Ting Fung. 2017. "Efforts and Challenges in Engineering the Genetic Code." Life 7, no. 1: 12.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.