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Life 2016, 6(3), 27; doi:10.3390/life6030027

Conservation of the Exon-Intron Structure of Long Intergenic Non-Coding RNA Genes in Eutherian Mammals

1
Department of Genetics, Institute for Quantitative Biomedical Sciences, Geisel School of Medicine, Dartmouth College, Hanover, NH 03755, USA
2
Information Engineering Branch, National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA
3
Department of Biomedical Informatics, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
4
Institute of Bioinformatics, University of Muenster, Muenster 48149, Germany
5
Computational Biology Branch, National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA
6
Novosibirsk State University, Novosibirsk 630090, Russia
*
Author to whom correspondence should be addressed.
Academic Editors: Alexander Bolshoy and David Deamer
Received: 18 March 2016 / Revised: 28 June 2016 / Accepted: 12 July 2016 / Published: 15 July 2016
(This article belongs to the Special Issue Structure and Evolution of Genome)
View Full-Text   |   Download PDF [1058 KB, uploaded 15 July 2016]   |  

Abstract

The abundance of mammalian long intergenic non-coding RNA (lincRNA) genes is high, yet their functions remain largely unknown. One possible way to study this important question is to use large-scale comparisons of various characteristics of lincRNA with those of protein-coding genes for which a large body of functional information is available. A prominent feature of mammalian protein-coding genes is the high evolutionary conservation of the exon-intron structure. Comparative analysis of putative intron positions in lincRNA genes from various mammalian genomes suggests that some lincRNA introns have been conserved for over 100 million years, thus the primary and/or secondary structure of these molecules is likely to be functionally important. View Full-Text
Keywords: lincRNA; exon; intron; non-coding RNA; genomic alignments; intron gain; intron loss lincRNA; exon; intron; non-coding RNA; genomic alignments; intron gain; intron loss
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Chernikova, D.; Managadze, D.; Glazko, G.V.; Makalowski, W.; Rogozin, I.B. Conservation of the Exon-Intron Structure of Long Intergenic Non-Coding RNA Genes in Eutherian Mammals. Life 2016, 6, 27.

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