Fitness Landscapes of Functional RNAs
AbstractThe notion of fitness landscapes, a map between genotype and fitness, was proposed more than 80 years ago. For most of this time data was only available for a few alleles, and thus we had only a restricted view of the whole fitness landscape. Recently, advances in genetics and molecular biology allow a more detailed view of them. Here we review experimental and theoretical studies of fitness landscapes of functional RNAs, especially aptamers and ribozymes. We find that RNA structures can be divided into critical structures, connecting structures, neutral structures and forbidden structures. Such characterisation, coupled with theoretical sequence-to-structure predictions, allows us to construct the whole fitness landscape. Fitness landscapes then can be used to study evolution, and in our case the development of the RNA world. View Full-Text
- Supplementary File 1:
XLSX-Document (XLSX, 25 KB)
Scifeed alert for new publicationsNever miss any articles matching your research from any publisher
- Get alerts for new papers matching your research
- Find out the new papers from selected authors
- Updated daily for 49'000+ journals and 6000+ publishers
- Define your Scifeed now
Kun, Á.; Szathmáry, E. Fitness Landscapes of Functional RNAs. Life 2015, 5, 1497-1517.
Kun Á, Szathmáry E. Fitness Landscapes of Functional RNAs. Life. 2015; 5(3):1497-1517.Chicago/Turabian Style
Kun, Ádám; Szathmáry, Eörs. 2015. "Fitness Landscapes of Functional RNAs." Life 5, no. 3: 1497-1517.