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Life 2013, 3(3), 486-501; doi:10.3390/life3030486

Formaldehyde—A Key Monad of the Biomolecular System

1,* , 2
1 Department of Medicinal Chemistry, Faculty of Life Science University of Vienna, Althanstr. 14, Vienna 1090, Austria 2 Department of Pharmaceutical Chemistry, University of Frankfurt, Max-von-Laue-Str. 9, Frankfurt D-60438, Germany Current address: Merial Ltd., 3239 Satellite Blvd., Duluth, GA 30096, USA. This publication is dedicated to Simon Eppacher, who died tragically in the time of the preparation of this manuscript.
* Author to whom correspondence should be addressed.
Received: 2 May 2013 / Revised: 17 July 2013 / Accepted: 30 July 2013 / Published: 16 August 2013
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Experiments will be presented and reviewed to support the hypothesis that the intrinsic reactivity of formaldehyde may lead to the formation of a rather comprehensive set of defined biomolecules, including D-glucose, thus fostering concepts of evolution considering the existence of a premetabolic system as a primordial step in the generation of life.
Keywords: formaldehyde; D-glucose; prebiotic; stereoelectronic effect; helical chirality formaldehyde; D-glucose; prebiotic; stereoelectronic effect; helical chirality
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Noe, C.R.; Freissmuth, J.; Richter, P.; Miculka, C.; Lachmann, B.; Eppacher, S. Formaldehyde—A Key Monad of the Biomolecular System. Life 2013, 3, 486-501.

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