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Life 2013, 3(3), 486-501; doi:10.3390/life3030486
Review

Formaldehyde—A Key Monad of the Biomolecular System

1,* , 2
,
2
,
2,†
,
1
 and
1,‡
1 Department of Medicinal Chemistry, Faculty of Life Science University of Vienna, Althanstr. 14, Vienna 1090, Austria 2 Department of Pharmaceutical Chemistry, University of Frankfurt, Max-von-Laue-Str. 9, Frankfurt D-60438, Germany Current address: Merial Ltd., 3239 Satellite Blvd., Duluth, GA 30096, USA. This publication is dedicated to Simon Eppacher, who died tragically in the time of the preparation of this manuscript.
* Author to whom correspondence should be addressed.
Received: 2 May 2013 / Revised: 17 July 2013 / Accepted: 30 July 2013 / Published: 16 August 2013
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Abstract

Experiments will be presented and reviewed to support the hypothesis that the intrinsic reactivity of formaldehyde may lead to the formation of a rather comprehensive set of defined biomolecules, including D-glucose, thus fostering concepts of evolution considering the existence of a premetabolic system as a primordial step in the generation of life.
Keywords: formaldehyde; D-glucose; prebiotic; stereoelectronic effect; helical chirality formaldehyde; D-glucose; prebiotic; stereoelectronic effect; helical chirality
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Noe, C.R.; Freissmuth, J.; Richter, P.; Miculka, C.; Lachmann, B.; Eppacher, S. Formaldehyde—A Key Monad of the Biomolecular System. Life 2013, 3, 486-501.

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