Next Article in Journal
Quantum Biological Channel Modeling and Capacity Calculation
Next Article in Special Issue
The Function of Gas Vesicles in Halophilic Archaea and Bacteria: Theories and Experimental Evidence
Previous Article in Journal
Life’s Order, Complexity, Organization, and Its Thermodynamic–Holistic Imperatives
Previous Article in Special Issue
Survival of the Fittest: Overcoming Oxidative Stress at the Extremes of Acid, Heat and Metal
Life 2012, 2(4), 364-376; doi:10.3390/life2040364
Review

Molecular Mechanisms of Survival Strategies in Extreme Conditions

1,* , 1
, 2
, 3
, 4
 and 5,6
1 Department of Physics, University of Messina, Viale D'Alcontres 31, P.O. Box 55-98166, Messina, Italy 2 Institut Laue Langevin, 6, Rue Jules Horowitz, F-38042 Grenoble Cedex 9, France 3 CNR-IOM-OGG, Institut Laue Langevin, 6, Rue Jules Horowitz, F-38042 Grenoble Cedex 9, France 4 ISIS Facility, Rutherford Appleton Laboratory, Chilton, Oxon, OX11 0QX, UK 5 Institute of Enzymology, Research Center for Natural Sciences, Hungarian Academy of Science, Budapest, Hungary 6 Department of Applied Biotechnology and Food Sciences, University of Technology and Economics, Budapest, Hungary
* Author to whom correspondence should be addressed.
Received: 24 October 2012 / Revised: 8 November 2012 / Accepted: 26 November 2012 / Published: 7 December 2012
(This article belongs to the Special Issue Extremophiles and Extreme Environments)
View Full-Text   |   Download PDF [532 KB, uploaded 7 December 2012]   |   Browse Figures

Abstract

Today, one of the major challenges in biophysics is to disclose the molecular mechanisms underlying biological processes. In such a frame, the understanding of the survival strategies in extreme conditions received a lot of attention both from the scientific and applicative points of view. Since nature provides precious suggestions to be applied for improving the quality of life, extremophiles are considered as useful model-systems. The main goal of this review is to present an overview of some systems, with a particular emphasis on trehalose playing a key role in several extremophile organisms. The attention is focused on the relation among the structural and dynamic properties of biomolecules and bioprotective mechanisms, as investigated by complementary spectroscopic techniques at low- and high-temperature values.
Keywords: survival strategies; molecular mechanisms; lysozyme; dUTPase; trehalose; structure; dynamics; spectroscopic techniques survival strategies; molecular mechanisms; lysozyme; dUTPase; trehalose; structure; dynamics; spectroscopic techniques
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Export to BibTeX |
EndNote


MDPI and ACS Style

Magazù, S.; Migliardo, F.; Gonzalez, M.A.; Mondelli, C.; Parker, S.F.; Vertessy, B.G. Molecular Mechanisms of Survival Strategies in Extreme Conditions. Life 2012, 2, 364-376.

View more citation formats

Related Articles

Article Metrics

Comments

Citing Articles

[Return to top]
Life EISSN 2075-1729 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert