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Life 2012, 2(4), 364-376; doi:10.3390/life2040364
Review

Molecular Mechanisms of Survival Strategies in Extreme Conditions

1,* , 1
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Received: 24 October 2012; in revised form: 8 November 2012 / Accepted: 26 November 2012 / Published: 7 December 2012
(This article belongs to the Special Issue Extremophiles and Extreme Environments)
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Abstract: Today, one of the major challenges in biophysics is to disclose the molecular mechanisms underlying biological processes. In such a frame, the understanding of the survival strategies in extreme conditions received a lot of attention both from the scientific and applicative points of view. Since nature provides precious suggestions to be applied for improving the quality of life, extremophiles are considered as useful model-systems. The main goal of this review is to present an overview of some systems, with a particular emphasis on trehalose playing a key role in several extremophile organisms. The attention is focused on the relation among the structural and dynamic properties of biomolecules and bioprotective mechanisms, as investigated by complementary spectroscopic techniques at low- and high-temperature values.
Keywords: survival strategies; molecular mechanisms; lysozyme; dUTPase; trehalose; structure; dynamics; spectroscopic techniques survival strategies; molecular mechanisms; lysozyme; dUTPase; trehalose; structure; dynamics; spectroscopic techniques
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Magazù, S.; Migliardo, F.; Gonzalez, M.A.; Mondelli, C.; Parker, S.F.; Vertessy, B.G. Molecular Mechanisms of Survival Strategies in Extreme Conditions. Life 2012, 2, 364-376.

AMA Style

Magazù S, Migliardo F, Gonzalez MA, Mondelli C, Parker SF, Vertessy BG. Molecular Mechanisms of Survival Strategies in Extreme Conditions. Life. 2012; 2(4):364-376.

Chicago/Turabian Style

Magazù, Salvatore; Migliardo, Federica; Gonzalez, Miguel A.; Mondelli, Claudia; Parker, Stewart F.; Vertessy, Beata G. 2012. "Molecular Mechanisms of Survival Strategies in Extreme Conditions." Life 2, no. 4: 364-376.

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