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Molecular Mechanisms of Survival Strategies in Extreme Conditions
Department of Physics, University of Messina, Viale D'Alcontres 31, P.O. Box 55-98166, Messina, Italy
Institut Laue Langevin, 6, Rue Jules Horowitz, F-38042 Grenoble Cedex 9, France
CNR-IOM-OGG, Institut Laue Langevin, 6, Rue Jules Horowitz, F-38042 Grenoble Cedex 9, France
ISIS Facility, Rutherford Appleton Laboratory, Chilton, Oxon, OX11 0QX, UK
Institute of Enzymology, Research Center for Natural Sciences, Hungarian Academy of Science, Budapest, Hungary
Department of Applied Biotechnology and Food Sciences, University of Technology and Economics, Budapest, Hungary
* Author to whom correspondence should be addressed.
Received: 24 October 2012; in revised form: 8 November 2012 / Accepted: 26 November 2012 / Published: 7 December 2012
Abstract: Today, one of the major challenges in biophysics is to disclose the molecular mechanisms underlying biological processes. In such a frame, the understanding of the survival strategies in extreme conditions received a lot of attention both from the scientific and applicative points of view. Since nature provides precious suggestions to be applied for improving the quality of life, extremophiles are considered as useful model-systems. The main goal of this review is to present an overview of some systems, with a particular emphasis on trehalose playing a key role in several extremophile organisms. The attention is focused on the relation among the structural and dynamic properties of biomolecules and bioprotective mechanisms, as investigated by complementary spectroscopic techniques at low- and high-temperature values.
Keywords: survival strategies; molecular mechanisms; lysozyme; dUTPase; trehalose; structure; dynamics; spectroscopic techniques
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Cite This Article
MDPI and ACS Style
Magazù, S.; Migliardo, F.; Gonzalez, M.A.; Mondelli, C.; Parker, S.F.; Vertessy, B.G. Molecular Mechanisms of Survival Strategies in Extreme Conditions. Life 2012, 2, 364-376.
Magazù S, Migliardo F, Gonzalez MA, Mondelli C, Parker SF, Vertessy BG. Molecular Mechanisms of Survival Strategies in Extreme Conditions. Life. 2012; 2(4):364-376.
Magazù, Salvatore; Migliardo, Federica; Gonzalez, Miguel A.; Mondelli, Claudia; Parker, Stewart F.; Vertessy, Beata G. 2012. "Molecular Mechanisms of Survival Strategies in Extreme Conditions." Life 2, no. 4: 364-376.