MicroRNA: A Linking between Astrocyte Dysfunction, Mild Cognitive Impairment, and Neurodegenerative Diseases
Abstract
:Simple Summary
Abstract
1. Introduction
2. Non-Coding RNAs as Key Epigenetic Factors
miRNAs: Biogenesis and Functions
3. The Crosstalk between MCI Factors and miRNA Dysregulation
4. Structure and Function of Astrocytes
miRNA Role in Astrocytes
5. Lipids in the Brain
6. The Biomarker Potential of miRNAs in CNS
7. miRNAs Altered in MCI and ND: Related Biological Processes
8. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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miRNA | Function | Disease | Organism | References |
---|---|---|---|---|
let-7a-5p | TGF-β/Smad signaling pathway regulation | Alzheimer | Rat | [168] |
miR-1 | Synaptic vesicle exocytosis attenuation | MCI-Cardiogenic dementia | Mouse | [54] |
miR-107 | Cell survival increase, lactate dehydrogenase leakage reduction, apoptosis inhibition | Alzheimer | Mouse | [171] |
miR-122-5p | PI3K-Akt signaling pathway | MCI-Alzheimer | Human | [162,181] |
miR-125a-5p | Inflammation, neuronal growth and activity | MCI-Ischemia | Human, rat | [70,114] |
miR-125b | TGF-β signaling pathway | MCI-Alzheimer -Ischemia | Human | [70,137,182] |
miR-128 | Synaptic transmission reduction | MCI | Mouse | [55] |
miR-130b-3p | Apoptosis | MCI | Human | [155] |
miR-132-3p | Apoptosis inhibition | MCI-Alzheimer | Human | [48,167] |
miR-135a | JAK2/STAT3 and ERK1/2 pathways | Alzheimer | Human | [137,183] |
miR-138 | Microglial activation | MCI | Mouse | [61] |
miR-142-3p | Apoptosis | MCI-Alzheimer | Human | [46,184] |
miR-143-3p | Angiogenesis, autophagy, and apoptosis increase | MCI- Alzheimer–Ischemia-Multiple sclerosis-Mesial Temporal Lobe-Epilepsy | Human, rat | [69,70,162,173,174] |
miR-146a-5p | Inflammation | MCI-Alzheimer | Human, mouse | [65,137,155] |
miR-148a-3p | Senescence | MCI | Human | [155] |
miR-155 | Neuroinflammation and neurodegeneration, BBB function loss | MCI-Alzheimer-Mesial Temporal Lobe Epilepsy-Multiple sclerosis | Human | [137,174,175,185] |
miR-15a/16-1 | Inflammation | Vascular cognitive impairment and dementia | Mouse | [60] |
miR-16 | Regulation of the serotonin transporter | Alzheimer | Rat | [148] |
miR-16-5p | Inflammation, neuronal growth and activity, cell cycle arrest, and apoptosis | MCI-ALS | Rat, mouse | [114,115,172] |
miR-17-5p | Neuronal apoptosis and inflammation reduction | MCI-Ischemia | Rat | [118] |
miR-181a-5p | Angiogenesis, TGF-β signaling pathway | MCI | Human | [4,155] |
miR-181c-3p | Axonal guidance signaling, TGF-β signaling | Multiple sclerosis | Human | [173,186] |
miR-181c-5p | Neurotrophin signaling pathway | MCI-Alzheimer-Multiple sclerosis | Human | [4,161,173] |
miR-182 | Inflammation | MCI | Mouse | [65] |
miR-191 | Apoptosis, inflammation | MCI | Human, rat | [182,187] |
miR-192-5p | TGF-β signaling pathway | MCI | Human | [155,188] |
miR-195-5p | β-amyloid load and tau hyperphosphorylation reduction, and apoptosis inhibition | MCI-Alzheimer | Human | [162,189,190] |
miR-200b | Inflammation | MCI | Mouse | [65] |
miR-210-3p | Apoptosis/proliferation | MCI-Alzheimer | Human, rat | [4,161,191] |
miR-21-5p | Axonal regeneration, neuronal protection | ALS | Human | [172] |
miR-27a-3p | β-amyloid load increase | Alzheimer | Human | [162] |
miR-27b-3p | Neurotrophin signaling pathway, β-amyloid load decrease | MCI-Alzheimer | Human | [4,162] |
miR-29a | Apoptosis reduction, mitochondrial function improvement | MCI-Ischemia | Rat, mouse | [116] |
miR-29b | Arachidonic acid metabolism, neurodegeneration reduction | MCI-Ischemia | Rat, mouse | [117] |
miR-29c | Neurite outgrowth promotion | MCI-Alzheimer | Human, mouse | [162,192] |
miR-30a-3p | Inflammation | MCI | Human | [155] |
miR-31-5p | Inflammation, BBB integrity impairment, apoptosis increase | MCI | Rat, mouse | [57,59] |
miR-3180 | Neurotrophin signaling pathway | Alzheimer | Human | [150,151] |
miR-324-5p | β-amyloid load increase | Alzheimer | Human | [162] |
miR-335-5p | Key regulator of AD-related gene networks | MCI-Alzheimer | Human | [162,193] |
miR-375 | Aralkylamine N-acetyltransferase expression and melatonin secretion decrease | Multiple sclerosis | Human | [173,194] |
miR-384 | Long-term potentiation | MCI-Alzheimer | Human, rat | [164,195] |
miR-451a | Neuronal differentiation promotion | MCI | Mouse | [53] |
miR-455-3p | Apoptosis, inflammation | MCI | Human, rat | [4,196] |
miR-4632-5p | Insulin resistance | MCI | Human | [149,150] |
miR-486-5p | Apoptosis increase, aging process | ALS | Human | [197,198,199] |
miR-567 | Apoptosis | MCI-Alzheimer | Human | [157] |
miR-629-5p | Apoptosis inhibition | Multiple sclerosis | Human | [173,200] |
miR-7 | Cellular ROS | Parkinson | Human, mouse | [146,201] |
miR-873a-5p | Repairer phenotype | Traumatic brain injury | Human | [113] |
miR-92a-3p | TGF-β signaling pathway | MCI-Alzheimer-ALS | Human | [4,161,172,199] |
miR-92b-3p | Cell viability increase, neurite growth, and functional recovery | MCI-Ischemia | Rat | [119,120] |
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Ramírez, A.E.; Gil-Jaramillo, N.; Tapias, M.A.; González-Giraldo, Y.; Pinzón, A.; Puentes-Rozo, P.J.; Aristizábal-Pachón, A.F.; González, J. MicroRNA: A Linking between Astrocyte Dysfunction, Mild Cognitive Impairment, and Neurodegenerative Diseases. Life 2022, 12, 1439. https://doi.org/10.3390/life12091439
Ramírez AE, Gil-Jaramillo N, Tapias MA, González-Giraldo Y, Pinzón A, Puentes-Rozo PJ, Aristizábal-Pachón AF, González J. MicroRNA: A Linking between Astrocyte Dysfunction, Mild Cognitive Impairment, and Neurodegenerative Diseases. Life. 2022; 12(9):1439. https://doi.org/10.3390/life12091439
Chicago/Turabian StyleRamírez, Angelica E., Natalia Gil-Jaramillo, María Alejandra Tapias, Yeimy González-Giraldo, Andrés Pinzón, Pedro J. Puentes-Rozo, Andrés Felipe Aristizábal-Pachón, and Janneth González. 2022. "MicroRNA: A Linking between Astrocyte Dysfunction, Mild Cognitive Impairment, and Neurodegenerative Diseases" Life 12, no. 9: 1439. https://doi.org/10.3390/life12091439