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Symmetry 2010, 2(2), 1180-1200; doi:10.3390/sym2021180
Article

Experimental Test of L- and D-Amino Acid Binding to L- and D-Codons Suggests that Homochirality and Codon Directionality Emerged with the Genetic Code

Received: 9 June 2010; in revised form: 18 June 2010 / Accepted: 22 June 2010 / Published: 23 June 2010
(This article belongs to the Special Issue Symmetry of Life and Homochirality)
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Abstract: L-amino acids bind preferentially to their D-codons, but almost nothing is known about whether D-amino acids correspondingly prefer L-codons, or how codon directionality affects amino acid binding. To investigate these issues, two D-RNA-oligonucleotides having inverse base sequences (D-CGUA and D-AUGC) and their corresponding L-RNA-oligonucleotides (L-CGUA and L-AUGC) were synthesized and their affinity determined for Gly and eleven pairs of L- and D-amino acids. The data support the hypothesis (Root-Bernstein, Bioessays 2007; 29: 689–698) that homochirality and codon directionality emerged as a function of the origin of the genetic code itself. Further tests involving amplification methods are proposed.
Keywords: homochirality; origin of genetic code; codon; amino acid; chiral binding; molecular complementarity; origin of life; selectivity homochirality; origin of genetic code; codon; amino acid; chiral binding; molecular complementarity; origin of life; selectivity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Root-Bernstein, R. Experimental Test of L- and D-Amino Acid Binding to L- and D-Codons Suggests that Homochirality and Codon Directionality Emerged with the Genetic Code. Symmetry 2010, 2, 1180-1200.

AMA Style

Root-Bernstein R. Experimental Test of L- and D-Amino Acid Binding to L- and D-Codons Suggests that Homochirality and Codon Directionality Emerged with the Genetic Code. Symmetry. 2010; 2(2):1180-1200.

Chicago/Turabian Style

Root-Bernstein, Robert. 2010. "Experimental Test of L- and D-Amino Acid Binding to L- and D-Codons Suggests that Homochirality and Codon Directionality Emerged with the Genetic Code." Symmetry 2, no. 2: 1180-1200.


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