Next Article in Journal
Pyrrolobenzodiazepine Antibody-Drug Conjugates Designed for Stable Thiol Conjugation
Next Article in Special Issue
Enzyme-Based Labeling Strategies for Antibody–Drug Conjugates and Antibody Mimetics
Previous Article in Journal
Monoclonal Antibody: A New Treatment Strategy against Multiple Myeloma
Article Menu

Export Article

Open AccessFeature PaperReview
Antibodies 2017, 6(4), 19; https://doi.org/10.3390/antib6040019

Antagonist Anti-CD28 Therapeutics for the Treatment of Autoimmune Disorders

1
OSE Immunotherapeutics, 44200 Nantes, France
2
Centre de Recherche en Transplantation et Immunologie (CRTI) UMR1064, INSERM, Université de Nantes, 44035 Nantes, France
3
Institut de Transplantation Urologie Néphrologie (ITUN), CHU Nantes, 44093 Nantes, France
4
Biomedical Primate Research Centre, 2288 GJ Rijswijk, The Netherlands
5
Department Neuroscience, University of Groningen, University Medical Center, 9713 GZ Groningen, The Netherlands
6
Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, 1649-004 Lisbon, Portugal
7
Hospital Israelita Albert Einstein, Av. Albert Einstein 627-701, 2-SS Bloco A, 05651-901 São Paulo, Brazil
8
Nuffield Department of Surgical Sciences, University of Oxford, Oxford OX3 9DU, UK
*
Author to whom correspondence should be addressed.
Received: 26 October 2017 / Revised: 16 November 2017 / Accepted: 18 November 2017 / Published: 21 November 2017
(This article belongs to the Special Issue Therapeutic Antibodies)
Full-Text   |   PDF [480 KB, uploaded 23 November 2017]   |  

Abstract

The effector functions of T lymphocytes are responsible for most autoimmune disorders and act by directly damaging tissues or by indirectly promoting inflammation and antibody responses. Co-stimulatory and co-inhibitory T cell receptor molecules are the primary pharmacological targets that enable interference with immune-mediated diseases. Among these, selective CD28 antagonists have drawn special interest, since they tip the co-stimulation/co-inhibition balance towards efficiently inhibiting effector T cells while promoting suppression by pre-existing regulatory T-cells. After having demonstrated outstanding therapeutic efficacy in multiple models of autoimmunity, inflammation and transplantation, and safety in phase-I studies in humans, selective CD28 antagonists are currently in early clinical development for the treatment of systemic lupus erythematous and rheumatoid arthritis. Here, we review the available proof of concept studies for CD28 antagonists in autoimmunity, with a special focus on the mechanisms of action. View Full-Text
Keywords: autoimmunity; T cell costimulation; antibodies autoimmunity; T cell costimulation; antibodies
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Vanhove, B.; Poirier, N.; Fakhouri, F.; Laurent, L.; ’t Hart, B.; Papotto, P.H.; Rizzo, L.V.; Zaitsu, M.; Issa, F.; Wood, K.; Soulillou, J.-P.; Blancho, G. Antagonist Anti-CD28 Therapeutics for the Treatment of Autoimmune Disorders. Antibodies 2017, 6, 19.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Antibodies EISSN 2073-4468 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top