Next Article in Journal
Acknowledgement to Reviewers of Antibodies in 2013
Next Article in Special Issue
Role of B Cells in Breaking and Maintaining Tolerance to Clotting Factor VIII in Congenital and Acquired Hemophilia A
Previous Article in Journal / Special Issue
B Cell Tolerance in Health and Disease
Antibodies 2014, 3(1), 130-152; doi:10.3390/antib3010130

From Donor to Recipient: Current Questions Relating to Humoral Alloimmunization

1,2, 1,3, 2, 1, 1,2, 1,2, 1,3 and 1,2,*
1 GIMAP-EA3064, Université de Lyon, 42023 Saint-Etienne, France 2 EFS Auvergne-Loire, 42023 Saint-Etienne, France 3 Service de Néphrologie, Dialyse et Transplantation Rénale, Hôpital Nord, CHU de Saint-Etienne, PRES Université de Lyon, 42270 Saint Priest en Jarez, France
* Author to whom correspondence should be addressed.
Received: 30 October 2013 / Revised: 16 January 2014 / Accepted: 29 January 2014 / Published: 20 February 2014
(This article belongs to the Special Issue B Cells and Immunological Tolerance)
View Full-Text   |   Download PDF [243 KB, uploaded 20 February 2014]


Alloimmunization is an undesirable iatrogenic effect of transfusion and transplantation. In fact, recipients can be considered as responders or not responders, in a continuum from tolerance, including organ transplantation and transfusion, to polyimmunized and refractory patients. New models and large studies have enabled a better understanding of the mechanisms that induce specific alloantibody (alloAb) generation. Here, we focus on risk factors of alloimmunization. We review the alloantibody characteristics, summarize the different leukocytes involved in their induction, and suggest some hypotheses.
Keywords: transfusion; transplantation; alloimmunization; tolerance; HLA transfusion; transplantation; alloimmunization; tolerance; HLA
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote |
MDPI and ACS Style

Prigent, A.; Maillard, N.; Absi, L.; Aloui, C.; Cognasse, F.; Laradi, S.; Mariat, C.; Garraud, O. From Donor to Recipient: Current Questions Relating to Humoral Alloimmunization. Antibodies 2014, 3, 130-152.

View more citation formats

Related Articles

Article Metrics


[Return to top]
Antibodies EISSN 2073-4468 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert