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Antibodies 2014, 3(1), 130-152; doi:10.3390/antib3010130
Review

From Donor to Recipient: Current Questions Relating to Humoral Alloimmunization

1,2, 1,3, 2, 1, 1,2, 1,2, 1,3 and 1,2,*
Received: 30 October 2013; in revised form: 16 January 2014 / Accepted: 29 January 2014 / Published: 20 February 2014
(This article belongs to the Special Issue B Cells and Immunological Tolerance)
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Abstract: Alloimmunization is an undesirable iatrogenic effect of transfusion and transplantation. In fact, recipients can be considered as responders or not responders, in a continuum from tolerance, including organ transplantation and transfusion, to polyimmunized and refractory patients. New models and large studies have enabled a better understanding of the mechanisms that induce specific alloantibody (alloAb) generation. Here, we focus on risk factors of alloimmunization. We review the alloantibody characteristics, summarize the different leukocytes involved in their induction, and suggest some hypotheses.
Keywords: transfusion; transplantation; alloimmunization; tolerance; HLA transfusion; transplantation; alloimmunization; tolerance; HLA
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Prigent, A.; Maillard, N.; Absi, L.; Aloui, C.; Cognasse, F.; Laradi, S.; Mariat, C.; Garraud, O. From Donor to Recipient: Current Questions Relating to Humoral Alloimmunization. Antibodies 2014, 3, 130-152.

AMA Style

Prigent A, Maillard N, Absi L, Aloui C, Cognasse F, Laradi S, Mariat C, Garraud O. From Donor to Recipient: Current Questions Relating to Humoral Alloimmunization. Antibodies. 2014; 3(1):130-152.

Chicago/Turabian Style

Prigent, Antoine; Maillard, Nicolas; Absi, Léna; Aloui, Chaker; Cognasse, Fabrice; Laradi, Sandrine; Mariat, Christophe; Garraud, Olivier. 2014. "From Donor to Recipient: Current Questions Relating to Humoral Alloimmunization." Antibodies 3, no. 1: 130-152.


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