Next Article in Journal
The drnf1 Gene from the Drought-Adapted Cyanobacterium Nostoc flagelliforme Improved Salt Tolerance in Transgenic Synechocystis and Arabidopsis Plant
Previous Article in Journal
Wnt Effector TCF4 Is Dispensable for Wnt Signaling in Human Cancer Cells
Previous Article in Special Issue
Sequencing of Supernumerary Chromosomes of Red Fox and Raccoon Dog Confirms a Non-Random Gene Acquisition by B Chromosomes
Article Menu

Export Article

Open AccessReview
Genes 2018, 9(9), 440; https://doi.org/10.3390/genes9090440

L Chromosome Behaviour and Chromosomal Imprinting in Sciara Coprophila

1
Nazarbayev University School of Medicine, 5/1 Kerei, Zhanibek Khandar Street, Astana Z05K4F4, Kazakhstan
2
Epigenetics Laboratory, Department of Natural Sciences, Novosibirsk State University, Pirogov str. 2, Novosibirsk 630090, Russia
3
Genomics laboratory, Institute of Molecular and Cellular Biology SB RAS, Lavrentyev ave, 8/2, Novosibirsk 630090, Russia
*
Author to whom correspondence should be addressed.
Received: 19 July 2018 / Revised: 29 August 2018 / Accepted: 29 August 2018 / Published: 3 September 2018
(This article belongs to the Special Issue Evolution, Composition and Regulation of Supernumerary B Chromosomes)
Full-Text   |   PDF [13300 KB, uploaded 3 September 2018]   |  

Abstract

The retention of supernumerary chromosomes in the germ-line of Sciara coprophila is part of a highly-intricate pattern of chromosome behaviours that have fascinated cytogeneticists for over 80 years. Germ-line limited (termed L or “limited”) chromosomes are cytologically heterochromatic and late-replicating, with more recent studies confirming they possess epigenetic hallmarks characteristic of constitutive heterochromatin. Little is known about their genetic constitution although they have been found to undergo cycles of condensation and de-condensation at different stages of development. Unlike most supernumeraries, the L chromosomes in S. coprophila are thought to be indispensable, although in two closely related species Sciara ocellaris and Sciara reynoldsi the L chromosomes, have been lost during evolution. Here, we review what we know about L chromosomes in Sciara coprophila. We end by discussing how study of the L chromosome condensation cycle has provided insight into the site and timing of both the erasure of parental “imprints” and also the placement of a putative “imprint” that might be carried by the sperm into the egg. View Full-Text
Keywords: supernumerary chromosomes; heterochromatin; parent-of-origin effects; paternal X chromosome; maternal X chromosome; controlling element supernumerary chromosomes; heterochromatin; parent-of-origin effects; paternal X chromosome; maternal X chromosome; controlling element
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Singh, P.B.; Belyakin, S.N. L Chromosome Behaviour and Chromosomal Imprinting in Sciara Coprophila. Genes 2018, 9, 440.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Genes EISSN 2073-4425 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top