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Genes 2018, 9(7), 340; https://doi.org/10.3390/genes9070340

Applications of Yeast Synthetic Biology Geared towards the Production of Biopharmaceuticals

1
Department of Molecular Sciences, Macquarie University, Sydney 2109, Australia
2
Chancellery, Macquarie University, Sydney 2109, Australia
*
Author to whom correspondence should be addressed.
Received: 4 June 2018 / Revised: 1 July 2018 / Accepted: 2 July 2018 / Published: 6 July 2018
(This article belongs to the Special Issue Emerging Applications in Synthetic Biology)
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Abstract

Engineered yeast are an important production platform for the biosynthesis of high-value compounds with medical applications. Recent years have witnessed several new developments in this area, largely spurred by advances in the field of synthetic biology and the elucidation of natural metabolic pathways. This minireview presents an overview of synthetic biology applications for the heterologous biosynthesis of biopharmaceuticals in yeast and demonstrates the power and potential of yeast cell factories by highlighting several recent examples. In addition, an outline of emerging trends in this rapidly-developing area is discussed, hinting upon the potential state-of-the-art in the years ahead. View Full-Text
Keywords: biopharmaceuticals; biologics; natural products; recombinant proteins; Saccharomyces cerevisiae; synthetic biology; yeast biopharmaceuticals; biologics; natural products; recombinant proteins; Saccharomyces cerevisiae; synthetic biology; yeast
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Walker, R.S.K.; Pretorius, I.S. Applications of Yeast Synthetic Biology Geared towards the Production of Biopharmaceuticals. Genes 2018, 9, 340.

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