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Genes 2018, 9(2), 67; https://doi.org/10.3390/genes9020067

RhoB: Team Oncogene or Team Tumor Suppressor?

1
Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
2
Department of Chemical and Biomolecular Engineering, The Johns Hopkins University, Baltimore, MD 21218, USA
*
Author to whom correspondence should be addressed.
Received: 3 January 2018 / Revised: 21 January 2018 / Accepted: 24 January 2018 / Published: 30 January 2018
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Abstract

Although Rho GTPases RhoA, RhoB, and RhoC share more than 85% amino acid sequence identity, they play very distinct roles in tumor progression. RhoA and RhoC have been suggested in many studies to contribute positively to tumor development, but the role of RhoB in cancer remains elusive. RhoB contains a unique C-terminal region that undergoes specific post-translational modifications affecting its localization and function. In contrast to RhoA and RhoC, RhoB not only localizes at the plasma membrane, but also on endosomes, multivesicular bodies and has even been identified in the nucleus. These unique features are what contribute to the diversity and potentially opposing functions of RhoB in the tumor microenvironment. Here, we discuss the dualistic role that RhoB plays as both an oncogene and tumor suppressor in the context of cancer development and progression. View Full-Text
Keywords: cancer progression; tumor suppressor genes; oncojanus genes; oncogene; RhoB; Rho GTPases cancer progression; tumor suppressor genes; oncojanus genes; oncogene; RhoB; Rho GTPases
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Ju, J.A.; Gilkes, D.M. RhoB: Team Oncogene or Team Tumor Suppressor? Genes 2018, 9, 67.

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