Next Article in Journal
Time to Spread Your Wings: A Review of the Avian Ancient DNA Field
Previous Article in Journal
Evolutionary Origins of Cancer Driver Genes and Implications for Cancer Prognosis
Article Menu
Issue 7 (July) cover image

Export Article

Open AccessArticle
Genes 2017, 8(7), 183; doi:10.3390/genes8070183

Genetic Contribution to Alcohol Dependence: Investigation of a Heterogeneous German Sample of Individuals with Alcohol Dependence, Chronic Alcoholic Pancreatitis, and Alcohol-Related Cirrhosis

1
Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, 68159 Mannheim, Germany
2
Human Genomics Research Group, Department of Biomedicine, University and University Hospital Basel, 4031 Basel, Switzerland
3
Institute of Medical Genetics and Pathology, University Hospital Basel, 4031 Basel, Switzerland
4
Division of Applied Bioinformatics (G200), German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany
5
Institute of Human Genetics, University of Bonn, 53127 Bonn, Germany
6
Department of Genomics, Life & Brain Center, University of Bonn, 53127 Bonn, Germany
7
University Hospital of Child and Adolescent Psychiatry and Psychotherapy, University of Bern, 3000 Bern 60, Switzerland
8
Department of Psychiatry (U.P.K.), University of Basel, CH-4002 Basel, Switzerland
9
Department of Psychiatry and Psychotherapy, University of Regensburg, 93053 Regensburg, Germany
10
Psychiatric Health Care Aargau, 5210 Windisch, Switzerland
11
Private Hospital Meiringen, 3860 Meiringen, Switzerland
12
Psychiatric Hospital, Ludwig Maximilians University, 80336 Munich, Germany
13
Department of Psychiatry, University of Bonn, 53105 Bonn, Germany
14
Department of Psychiatry and Psychotherapy, University of Düsseldorf, 40629 Düsseldorf, Germany
15
Department of Psychiatry, University of Mainz, 55131 Mainz, Germany
16
LVR-Hospital Essen, Department of Psychiatry and Psychotherapy, Medical Faculty, University of Duisburg-Essen, 45147 Essen, Germany
17
Department of Statistical Genetics, Max-Planck-Institute of Psychiatry, 80804 Munich, Germany
18
Department of Psychiatric Pharmacogenetics, Max-Planck-Institute of Psychiatry, 80804 Munich, Germany
19
Department of Molecular Psychology, Max-Planck-Institute of Psychiatry, 80804 Munich, Germany
20
Department of Gastroenterology and Hepatology, University Hospital of Zurich, 8091 Zurich, Switzerland
21
Hirslanden Private Hospital, 8032 Hirslanden Zürich, Switzerland
22
Section of Hepatology, University Hospital Leipzig, 04103 Leipzig, Germany
23
Institute for Medical Informatics, Biometry, and Epidemiology, University Hospital of Essen, 45122 Essen, Germany
24
Department of Animal Physiology, University of Cologne, 50674 Cologne, Germany
25
Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Dresden Technical University, 01307 Dresden, Germany
26
Medical Department 1, University Hospital Dresden, TU Dresden, 01307 Dresden, Germany
27
Institute of Psychopharmacology, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, 68159 Mannheim, Germany
28
Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, 68159 Mannheim, Germany
29
Department of Internal Medicine I, Martin Luther University Halle, 06120 Halle (Saale), Germany
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 27 June 2017 / Accepted: 11 July 2017 / Published: 17 July 2017
(This article belongs to the Section Human Genomics and Genetic Diseases)
View Full-Text   |   Download PDF [271 KB, uploaded 17 July 2017]

Abstract

The present study investigated the genetic contribution to alcohol dependence (AD) using genome-wide association data from three German samples. These comprised patients with: (i) AD; (ii) chronic alcoholic pancreatitis (ACP); and (iii) alcohol-related liver cirrhosis (ALC). Single marker, gene-based, and pathway analyses were conducted. A significant association was detected for the ADH1B locus in a gene-based approach (puncorrected = 1.2 × 10−6; pcorrected = 0.020). This was driven by the AD subsample. No association with ADH1B was found in the combined ACP + ALC sample. On first inspection, this seems surprising, since ADH1B is a robustly replicated risk gene for AD and may therefore be expected to be associated also with subgroups of AD patients. The negative finding in the ACP + ALC sample, however, may reflect genetic stratification as well as random fluctuation of allele frequencies in the cases and controls, demonstrating the importance of large samples in which the phenotype is well assessed. View Full-Text
Keywords: alcohol dependence; chronic alcoholic pancreatitis; alcoholic liver cirrhosis; genome-wide association study; alcohol dehydrogenase; ADH1B; ADH1C alcohol dependence; chronic alcoholic pancreatitis; alcoholic liver cirrhosis; genome-wide association study; alcohol dehydrogenase; ADH1B; ADH1C
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Supplementary material

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Treutlein, J.; Frank, J.; Streit, F.; Reinbold, C.S.; Juraeva, D.; Degenhardt, F.; Rietschel, L.; Witt, S.H.; Forstner, A.J.; Ridinger, M.; Strohmaier, J.; Wodarz, N.; Dukal, H.; Foo, J.C.; Hoffmann, P.; Herms, S.; Heilmann-Heimbach, S.; Soyka, M.; Maier, W.; Gaebel, W.; Dahmen, N.; Scherbaum, N.; Müller-Myhsok, B.; Lucae, S.; Ising, M.; Stickel, F.; Berg, T.; Roggenbuck, U.; Jöckel, K.-H.; Scholz, H.; Zimmermann, U.S.; Buch, S.; Sommer, W.H.; Spanagel, R.; Brors, B.; Cichon, S.; Mann, K.; Kiefer, F.; Hampe, J.; Rosendahl, J.; Nöthen, M.M.; Rietschel, M. Genetic Contribution to Alcohol Dependence: Investigation of a Heterogeneous German Sample of Individuals with Alcohol Dependence, Chronic Alcoholic Pancreatitis, and Alcohol-Related Cirrhosis. Genes 2017, 8, 183.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Genes EISSN 2073-4425 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top