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Genes 2017, 8(7), 176; doi:10.3390/genes8070176

The Telomeric Complex and Metabolic Disease

1
First Department of Medicine, University of Lübeck, Ratzeburger Allee 160, 23562 Lübeck, Germany
2
Stratlab Ltd., March, Cambridgeshire PE15 8QD, UK
3
German Center for Diabetes Research (DZD), Ingolstädter Landstraße 1, 85764 Neuherberg, Germany
4
Institute of Neurobiology, University of Lübeck, Ratzeburger Allee 160, 23562 Lübeck, Germany
*
Author to whom correspondence should be addressed.
Received: 5 May 2017 / Revised: 26 June 2017 / Accepted: 30 June 2017 / Published: 7 July 2017
(This article belongs to the Section Human Genomics and Genetic Diseases)
View Full-Text   |   Download PDF [512 KB, uploaded 7 July 2017]   |  

Abstract

The attrition of telomeres is believed to be a key event not only in mammalian aging, but also in disturbed nutrient sensing, which could lead to numerous metabolic dysfunctions. The current debate focuses mainly on the question whether telomere shortening, e.g., as a heritable trait, may act as a cause or rather represents a consequence of such chronic diseases. This review discusses the damaging events that ultimately may lead or contribute to telomere shortening and can be associated with metabolic diseases. View Full-Text
Keywords: metabolic diseases; leucocyte telomere length; diabetes; obesity telomere shortening metabolic diseases; leucocyte telomere length; diabetes; obesity telomere shortening
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Kirchner, H.; Shaheen, F.; Kalscheuer, H.; Schmid, S.M.; Oster, H.; Lehnert, H. The Telomeric Complex and Metabolic Disease. Genes 2017, 8, 176.

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