MYC—Master Regulator of the Cancer Epigenome and Transcriptome
AbstractOverexpression of MYC is a hallmark of many human cancers. The MYC oncogene has long been thought to execute its neoplastic functions by acting as a classic transcription factor, deregulating the expression of a large number of specific target genes. However, MYC’s influence on many of these target genes is rather modest and there is little overlap between MYC regulated genes in different cell types, leaving many mechanistic questions unanswered. Recent advances in the field challenge the dogma further, revealing a role for MYC that extends beyond the traditional concept of a sequence-specific transcription factor. In this article, we review MYC’s function as a regulator of the cancer epigenome and transcriptome. We outline our current understanding of how MYC regulates chromatin structure in both a site-specific and genome-wide fashion, and highlight the implications for therapeutic strategies for cancers with high MYC expression. View Full-Text
Scifeed alert for new publicationsNever miss any articles matching your research from any publisher
- Get alerts for new papers matching your research
- Find out the new papers from selected authors
- Updated daily for 49'000+ journals and 6000+ publishers
- Define your Scifeed now
Poole, C.J.; van Riggelen, J. MYC—Master Regulator of the Cancer Epigenome and Transcriptome. Genes 2017, 8, 142.
Poole CJ, van Riggelen J. MYC—Master Regulator of the Cancer Epigenome and Transcriptome. Genes. 2017; 8(5):142.Chicago/Turabian Style
Poole, Candace J.; van Riggelen, Jan. 2017. "MYC—Master Regulator of the Cancer Epigenome and Transcriptome." Genes 8, no. 5: 142.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.