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Genes 2017, 8(5), 138; doi:10.3390/genes8050138

DNA Methylation Dynamics and Cocaine in the Brain: Progress and Prospects

1
Department of Psychiatry, McGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University, Verdun, QC H4H 1R3, Canada
2
Department of Neurology, University of Miami Miller School of Medicine, University of Miami, Coral Gables, FL 33146, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Dennis R. Grayson
Received: 8 March 2017 / Accepted: 4 April 2017 / Published: 12 May 2017
(This article belongs to the Special Issue Role of Epigenetic Gene Regulation in Brain Function)
View Full-Text   |   Download PDF [1011 KB, uploaded 12 May 2017]   |  

Abstract

Cytosine modifications, including DNA methylation, are stable epigenetic marks that may translate environmental change into transcriptional regulation. Research has begun to investigate DNA methylation dynamics in relation to cocaine use disorders. Specifically, DNA methylation machinery, including methyltransferases and binding proteins, are dysregulated in brain reward pathways after chronic cocaine exposure. In addition, numerous methylome-wide and candidate promoter studies have identified differential methylation, at the nucleotide level, in rodent models of cocaine abuse and drug seeking behavior. This review highlights the current progress in the field of cocaine-related methylation, and offers considerations for future research. View Full-Text
Keywords: DNA methylation; epigenetics; cocaine; addiction DNA methylation; epigenetics; cocaine; addiction
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Vaillancourt, K.; Ernst, C.; Mash, D.; Turecki, G. DNA Methylation Dynamics and Cocaine in the Brain: Progress and Prospects. Genes 2017, 8, 138.

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