DNA Methylation Dynamics and Cocaine in the Brain: Progress and Prospects
AbstractCytosine modifications, including DNA methylation, are stable epigenetic marks that may translate environmental change into transcriptional regulation. Research has begun to investigate DNA methylation dynamics in relation to cocaine use disorders. Specifically, DNA methylation machinery, including methyltransferases and binding proteins, are dysregulated in brain reward pathways after chronic cocaine exposure. In addition, numerous methylome-wide and candidate promoter studies have identified differential methylation, at the nucleotide level, in rodent models of cocaine abuse and drug seeking behavior. This review highlights the current progress in the field of cocaine-related methylation, and offers considerations for future research. View Full-Text
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Vaillancourt, K.; Ernst, C.; Mash, D.; Turecki, G. DNA Methylation Dynamics and Cocaine in the Brain: Progress and Prospects. Genes 2017, 8, 138.
Vaillancourt K, Ernst C, Mash D, Turecki G. DNA Methylation Dynamics and Cocaine in the Brain: Progress and Prospects. Genes. 2017; 8(5):138.Chicago/Turabian Style
Vaillancourt, Kathryn; Ernst, Carl; Mash, Deborah; Turecki, Gustavo. 2017. "DNA Methylation Dynamics and Cocaine in the Brain: Progress and Prospects." Genes 8, no. 5: 138.
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