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Genes 2017, 8(5), 135; doi:10.3390/genes8050135

Combination of RNA Interference and Stem Cells for Treatment of Central Nervous System Diseases

1
Institute of Pharmacology, Taishan Medical University, Taian 271016, Shandong, China
2
Departments of Behavioral Medicine & Psychiatry and Physiology & Pharmacology, Blanchette Rockefeller Neurosciences Institute, West Virginia University Health Sciences Center, Morgantown, WV 26506, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Wenyi Gu
Received: 22 February 2017 / Revised: 27 April 2017 / Accepted: 28 April 2017 / Published: 6 May 2017
(This article belongs to the Special Issue RNA Interference 2016)
View Full-Text   |   Download PDF [4968 KB, uploaded 6 May 2017]   |  

Abstract

RNA interference (RNAi), including microRNAs, is an important player in the mediation of differentiation and migration of stem cells via target genes. It is used as a potential strategy for gene therapy for central nervous system (CNS) diseases. Stem cells are considered vectors of RNAi due to their capacity to deliver RNAi to other cells. In this review, we discuss the recent advances in studies of RNAi pathways in controlling neuronal differentiation and migration of stem cells. We also highlight the utilization of a combination of RNAi and stem cells in treatment of CNS diseases. View Full-Text
Keywords: RNA interference; miRNA pathway; stem cells; differentiation; central nervous system diseases RNA interference; miRNA pathway; stem cells; differentiation; central nervous system diseases
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Hou, X.-Q.; Wang, L.; Wang, F.-G.; Zhao, X.-M.; Zhang, H.-T. Combination of RNA Interference and Stem Cells for Treatment of Central Nervous System Diseases. Genes 2017, 8, 135.

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