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Genes 2017, 8(2), 72; doi:10.3390/genes8020072

Type 1 Diabetes Candidate Genes Linked to Pancreatic Islet Cell Inflammation and Beta-Cell Apoptosis

1
Copenhagen Diabetes Research Center (CPH-DIRECT), Department of Pediatrics, University Hospital Herlev and Gentofte, Herlev 2730, Denmark
2
Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen 2200, Denmark
*
Author to whom correspondence should be addressed.
Academic Editor: Rajkumar Dorajoo
Received: 8 January 2017 / Revised: 7 February 2017 / Accepted: 10 February 2017 / Published: 16 February 2017
(This article belongs to the Special Issue Genetics and Functional Genomics of Diabetes Mellitus)
View Full-Text   |   Download PDF [562 KB, uploaded 16 February 2017]   |  

Abstract

Type 1 diabetes (T1D) is a chronic immune-mediated disease resulting from the selective destruction of the insulin-producing pancreatic islet β-cells. Susceptibility to the disease is the result of complex interactions between environmental and genetic risk factors. Genome-wide association studies (GWAS) have identified more than 50 genetic regions that affect the risk of developing T1D. Most of these susceptibility loci, however, harbor several genes, and the causal variant(s) and gene(s) for most of the loci remain to be established. A significant part of the genes located in the T1D susceptibility loci are expressed in human islets and β cells and mounting evidence suggests that some of these genes modulate the β-cell response to the immune system and viral infection and regulate apoptotic β-cell death. Here, we discuss the current status of T1D susceptibility loci and candidate genes with focus on pancreatic islet cell inflammation and β-cell apoptosis. View Full-Text
Keywords: GWAS; beta-cell; gene expression; apoptosis GWAS; beta-cell; gene expression; apoptosis
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Størling, J.; Pociot, F. Type 1 Diabetes Candidate Genes Linked to Pancreatic Islet Cell Inflammation and Beta-Cell Apoptosis. Genes 2017, 8, 72.

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