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Genes 2017, 8(2), 55; doi:10.3390/genes8020055

Solving the Telomere Replication Problem

Aix Marseille Univ, CNRS, INSERM, Institut Paoli‐Calmettes, CRCM, Equipe labélisée Ligue Contre le Cancer, 13273 Marseille, France
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Received: 2 November 2016 / Accepted: 23 January 2017 / Published: 31 January 2017
(This article belongs to the Special Issue DNA Replication Controls)
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Abstract

Telomeres are complex nucleoprotein structures that protect the extremities of linear chromosomes. Telomere replication is a major challenge because many obstacles to the progression of the replication fork are concentrated at the ends of the chromosomes. This is known as the telomere replication problem. In this article, different and new aspects of telomere replication, that can threaten the integrity of telomeres, will be reviewed. In particular, we will focus on the functions of shelterin and the replisome for the preservation of telomere integrity View Full-Text
Keywords: Telomere; Telomere replication; G‐quadruplex; T‐loop; TERRA Telomere; Telomere replication; G‐quadruplex; T‐loop; TERRA
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Maestroni, L.; Matmati, S.; Coulon, S. Solving the Telomere Replication Problem. Genes 2017, 8, 55.

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