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Genes 2017, 8(2), 49; doi:10.3390/genes8020049

Regulation of Replication Fork Advance and Stability by Nucleosome Assembly

Department of Genome Biology, Andalusian Molecular Biology and Regenerative Medicine Center (CABIMER), Spanish National Research Council (CSIC), Seville 41092, Spain
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Academic Editor: Eishi Noguchi
Received: 25 November 2016 / Revised: 4 January 2017 / Accepted: 16 January 2017 / Published: 24 January 2017
(This article belongs to the Special Issue DNA Replication Controls)
View Full-Text   |   Download PDF [1082 KB, uploaded 24 January 2017]   |  

Abstract

The advance of replication forks to duplicate chromosomes in dividing cells requires the disassembly of nucleosomes ahead of the fork and the rapid assembly of parental and de novo histones at the newly synthesized strands behind the fork. Replication-coupled chromatin assembly provides a unique opportunity to regulate fork advance and stability. Through post-translational histone modifications and tightly regulated physical and genetic interactions between chromatin assembly factors and replisome components, chromatin assembly: (1) controls the rate of DNA synthesis and adjusts it to histone availability; (2) provides a mechanism to protect the integrity of the advancing fork; and (3) regulates the mechanisms of DNA damage tolerance in response to replication-blocking lesions. Uncoupling DNA synthesis from nucleosome assembly has deleterious effects on genome integrity and cell cycle progression and is linked to genetic diseases, cancer, and aging. View Full-Text
Keywords: DNA replication; chromatin assembly; DNA damage tolerance; replication fork stability; homologous recombination DNA replication; chromatin assembly; DNA damage tolerance; replication fork stability; homologous recombination
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Prado, F.; Maya, D. Regulation of Replication Fork Advance and Stability by Nucleosome Assembly. Genes 2017, 8, 49.

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