Next Article in Journal / Special Issue
The Mitochondrial Basis of Aging and Age-Related Disorders
Previous Article in Journal
Deciphering the Relationship between Obesity and Various Diseases from a Network Perspective
Previous Article in Special Issue
Mitochondria and α-Synuclein: Friends or Foes in the Pathogenesis of Parkinson’s Disease?
Article Menu
Issue 12 (December) cover image

Export Article

Open AccessArticle
Genes 2017, 8(12), 397; doi:10.3390/genes8120397

Proliferation Cycle Causes Age Dependent Mitochondrial Deficiencies and Contributes to the Aging of Stem Cells

Laboratory of Molecular Genetics, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
*
Author to whom correspondence should be addressed.
Academic Editors: Konstantin Khrapko and Dori Woods
Received: 31 October 2017 / Revised: 17 November 2017 / Accepted: 14 December 2017 / Published: 19 December 2017
(This article belongs to the Special Issue Mitochondria and Aging)
View Full-Text   |   Download PDF [5712 KB, uploaded 19 December 2017]   |  

Abstract

In addition to chronological aging, stem cells are also subject to proliferative aging during the adult life span. However, the consequences of proliferative cycle and their contributions to stem cells aging have not been well investigated. Using Drosophila female germ line stem cells as a model, we found that the replication cycle leads to the age dependent decline of female fecundity, and is a major factor causing developmental abnormalities in the progeny of old females. The proliferative aging does not cause telomere shortening, but causes an accumulation of mitochondrial DNA (mtDNA) mutations or rearrangements at the control region. We propose that damaging mutations on mtDNA caused by accumulation of proliferation cycles in aged stem cells may disrupt mitochondrial respiration chain and impair mtDNA replication and represent a conserved mechanism underlying stem cell aging. View Full-Text
Keywords: aging; stem cell; mitochondria; mtDNA; telomere; DNA replication; DNA rearrangement; rolling cycle amplification aging; stem cell; mitochondria; mtDNA; telomere; DNA replication; DNA rearrangement; rolling cycle amplification
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Ren, Q.; Zhang, F.; Xu, H. Proliferation Cycle Causes Age Dependent Mitochondrial Deficiencies and Contributes to the Aging of Stem Cells. Genes 2017, 8, 397.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Genes EISSN 2073-4425 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top