Next Article in Journal
High-Throughput Sequencing of Small RNA Transcriptomes in Maize Kernel Identifies miRNAs Involved in Embryo and Endosperm Development
Previous Article in Journal
Differential Expression of Serum MicroRNAs Supports CD4+ T Cell Differentiation into Th2/Th17 Cells in Severe Equine Asthma
Article Menu
Issue 12 (December) cover image

Export Article

Open AccessReview
Genes 2017, 8(12), 384; doi:10.3390/genes8120384

The Tumor Suppressor p53 in Mucosal Melanoma of the Head and Neck

Department of Otorhinolaryngology/Head and Neck Surgery, Technische Universität München, Ismaningerstr, 22, 81675 München, Germany
*
Author to whom correspondence should be addressed.
Academic Editors: Giuseppe Gasparre and Anna Maria Porcelli
Received: 9 November 2017 / Revised: 4 December 2017 / Accepted: 5 December 2017 / Published: 13 December 2017
(This article belongs to the Section Human Genomics and Genetic Diseases)
View Full-Text   |   Download PDF [760 KB, uploaded 13 December 2017]   |  

Abstract

Despite worldwide prevention programs, the incidence for cutaneous melanoma is continuously increasing. Mucosal melanoma (MM) represents a rare but highly aggressive phenotype of common melanoma with predilection in the sinonasal system. Far away from ultraviolet sun exposure, the molecular mechanisms underlying tumorigenesis and the highly aggressive clinical behavior are poorly understood. In many solid malignomas of the head and neck region, p53 tumor suppressor functions as oncogene due to p53 protein stabilizing mutation. Interestingly, the vast majority of MM demonstrates constitutively expressed p53 protein, with protein stabilizing mutations being rare. Abrogated activation of p53 target genes results in derogation of the apoptotic signal cascade and contributes to the strong resistance against chemotherapeutic agents activating p53 dependent apoptosis. The current review illustrates the role of p53 and its pathway in MM. View Full-Text
Keywords: mucosal melanoma; p53; Puma, N-ras; pathway; apoptosis mucosal melanoma; p53; Puma, N-ras; pathway; apoptosis
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Fritsche, M.K.; Knopf, A. The Tumor Suppressor p53 in Mucosal Melanoma of the Head and Neck. Genes 2017, 8, 384.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Genes EISSN 2073-4425 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top