Next Article in Journal
Gene Silencing of Argonaute5 Negatively Affects the Establishment of the Legume-Rhizobia Symbiosis
Next Article in Special Issue
Context-Dependent Role of IKKβ in Cancer
Previous Article in Journal
The Potential of Zebrafish as a Model Organism for Improving the Translation of Genetic Anticancer Nanomedicines
Article Menu

Export Article

Open AccessReview
Genes 2017, 8(12), 354; doi:10.3390/genes8120354

TRIM8: Making the Right Decision between the Oncogene and Tumour Suppressor Role

1
Institute of Biomembranes, Bioenergetics and Molecular Biotechnologies, IBIOM-CNR, Via G. Amendola, 165/A-70126 Bari, Italy
2
Institute for Biomedical Technologies ITB, CNR-Bari, Via G. Amendola, 122/D-70126 Bari, Italy
*
Author to whom correspondence should be addressed.
Received: 2 November 2017 / Revised: 20 November 2017 / Accepted: 23 November 2017 / Published: 28 November 2017
View Full-Text   |   Download PDF [1582 KB, uploaded 28 November 2017]   |  

Abstract

The TRIM8/GERP protein is a member of the TRIM family defined by the presence of a common domain structure composed of a tripartite motif including a RING-finger, one or two B-box domains, and a coiled-coil motif. The TRIM8 gene maps on chromosome 10 within a region frequently found deleted and rearranged in tumours and transcribes a 3.0-kB mRNA. Its expression is mostly ubiquitously in murine and human tissues, and in epithelial and lymphoid cells, it can be induced by IFNγ. The protein spans 551 aa and is highly conserved during evolution. TRIM8 plays divergent roles in many biological processes, including important functions in inflammation and cancer through regulating various signalling pathways. In regulating cell growth, TRIM8 exerts either a tumour suppressor action, playing a prominent role in regulating p53 tumour suppressor activity, or an oncogene function, through the positive regulation of the NF-κB pathway. The molecular mechanisms underlying this dual role in human cancer will be discussed in depth in this review, and it will highlight the challenge and importance of developing novel therapeutic strategies specifically aimed at blocking the pro-oncogenic arm of the TRIM8 signalling pathway without affecting its tumour suppressive effects. View Full-Text
Keywords: TRIM8; tumour suppressor; oncogene; stemness; innate immunity; p53; NF-κB TRIM8; tumour suppressor; oncogene; stemness; innate immunity; p53; NF-κB
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Caratozzolo, M.F.; Marzano, F.; Mastropasqua, F.; Sbisà, E.; Tullo, A. TRIM8: Making the Right Decision between the Oncogene and Tumour Suppressor Role. Genes 2017, 8, 354.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Genes EISSN 2073-4425 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top