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Genes 2017, 8(12), 346; doi:10.3390/genes8120346

Genome-Wide Analysis Reveals the Secondary Metabolome in Streptomyces kanasensis ZX01

1
Research & Development Center of Biorational Pesticide, Northwest A & F University, Yangling 712100, Shaanxi, China
2
College of Agriculture, Shihezi University, Shihezi 832000, Xinjiang, China
3
Agriculture Research institute, Tibet Academy of Agricultural and animal Husbandry Science, Lhasa 850032, Tibet, China
*
Author to whom correspondence should be addressed.
Academic Editor: Mattheos Koffas
Received: 15 August 2017 / Revised: 26 October 2017 / Accepted: 17 November 2017 / Published: 30 November 2017
(This article belongs to the Section Microbial Genetics and Genomics)
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Abstract

Streptomyces kanasensis ZX01 produces some antibiotics and a glycoprotein with antiviral activity. To further evaluate its biosynthetic potential, here we sequenced the 7,026,279 bp draft genome of S. kanasensis ZX01 and analyzed all identifiable secondary gene clusters for controlling natural products. More than 60 putative clusters were found in S. kanasensis ZX01, the majority of these biosynthetic loci are novel. In addition, the regulators for secondary metabolism in S. kanasensis ZX01 were abundant. The global regulator nsdA not only controls biosynthesis of some antibiotics, but also enhances production of glycoprotein GP-1 with antiviral activity. This study importantly reveals the powerful interplay between genomic analysis and studies of traditional natural product purification/production increasing. View Full-Text
Keywords: genome mining; secondary metabolism; nsdA; regulator; glycoprotein GP-1 genome mining; secondary metabolism; nsdA; regulator; glycoprotein GP-1
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Zhang, G.; Yu, D.; Sang, B.; Feng, J.; Han, L.; Zhang, X. Genome-Wide Analysis Reveals the Secondary Metabolome in Streptomyces kanasensis ZX01. Genes 2017, 8, 346.

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