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Genes 2017, 8(1), 2; doi:10.3390/genes8010002

Regulation and Function of Cdt1; A Key Factor in Cell Proliferation and Genome Stability

1
Curriculum in Genetics and Molecular Biology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
2
Department of Biochemistry and Biophysics, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Eishi Noguchi
Received: 6 November 2016 / Revised: 13 December 2016 / Accepted: 14 December 2016 / Published: 22 December 2016
(This article belongs to the Special Issue DNA Replication Controls)
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Abstract

Successful cell proliferation requires efficient and precise genome duplication followed by accurate chromosome segregation. The Cdc10-dependent transcript 1 protein (Cdt1) is required for the first step in DNA replication, and in human cells Cdt1 is also required during mitosis. Tight cell cycle controls over Cdt1 abundance and activity are critical to normal development and genome stability. We review here recent advances in elucidating Cdt1 molecular functions in both origin licensing and kinetochore–microtubule attachment, and we describe the current understanding of human Cdt1 regulation. View Full-Text
Keywords: cell cycle; DNA replication; genome instability; pre-RC; re-replication; ubiquitylation; cyclin-dependent kinase; geminin; Origin Recognition Complex (ORC); Minichromosome Maintenance (MCM) cell cycle; DNA replication; genome instability; pre-RC; re-replication; ubiquitylation; cyclin-dependent kinase; geminin; Origin Recognition Complex (ORC); Minichromosome Maintenance (MCM)
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Pozo, P.N.; Cook, J.G. Regulation and Function of Cdt1; A Key Factor in Cell Proliferation and Genome Stability. Genes 2017, 8, 2.

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