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Genes 2016, 7(12), 130; doi:10.3390/genes7120130

Dysregulated MicroRNA Expression Profiles and Potential Cellular, Circulating and Polymorphic Biomarkers in Non-Hodgkin Lymphoma

Genomics Research Centre, Institute of Health and Biomedical Innovation, School of Biomedical Sciences, Queensland University of Technology, 60 Musk Avenue, Kelvin Grove, QLD 4059, Australia
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Author to whom correspondence should be addressed.
Academic Editor: George A. Calin
Received: 29 September 2016 / Revised: 23 November 2016 / Accepted: 5 December 2016 / Published: 17 December 2016
(This article belongs to the Special Issue microRNAs and Other Non-Coding RNAs in Human Diseases)
View Full-Text   |   Download PDF [267 KB, uploaded 17 December 2016]

Abstract

A large number of studies have focused on identifying molecular biomarkers, including microRNAs (miRNAs) to aid in the diagnosis and prognosis of the most common subtypes of non-Hodgkin lymphoma (NHL), Diffuse Large B-cell Lymphoma and Follicular Lymphoma. NHL is difficult to diagnose and treat with many cases becoming resistant to chemotherapy, hence the need to identify improved biomarkers to aid in both diagnosis and treatment modalities. This review summarises more recent research on the dysregulated miRNA expression profiles found in NHL, as well as the regulatory role and biomarker potential of cellular and circulating miRNAs found in tissue and serum, respectively. In addition, the emerging field of research focusing on miRNA single nucleotide polymorphisms (miRSNPs) in genes of the miRNA biogenesis pathway, in miRNA genes themselves, and in their target sites may provide new insights on gene expression changes in these genes. These miRSNPs may impact miRNA networks and have been shown to play a role in a host of different cancer types including haematological malignancies. With respect to NHL, a number of SNPs in miRNA-binding sites in target genes have been shown to be associated with overall survival. View Full-Text
Keywords: B-cell lymphoma; lymphoid neoplasia; haematological malignancies; micro-RNA (miRNA/miR); circulating miRNA; miRSNP (micro-RNA single nucleotide polymorphism); biomarker B-cell lymphoma; lymphoid neoplasia; haematological malignancies; micro-RNA (miRNA/miR); circulating miRNA; miRSNP (micro-RNA single nucleotide polymorphism); biomarker
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Bradshaw, G.; Sutherland, H.G.; Haupt, L.M.; Griffiths, L.R. Dysregulated MicroRNA Expression Profiles and Potential Cellular, Circulating and Polymorphic Biomarkers in Non-Hodgkin Lymphoma. Genes 2016, 7, 130.

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