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Genes 2015, 6(4), 1113-1124; doi:10.3390/genes6041113

How Porin Heterogeneity and Trade-Offs Affect the Antibiotic Susceptibility of Gram-Negative Bacteria

School of Molecular Bioscience, University of Sydney, Sydney, NSW 2006, Australia
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Author to whom correspondence should be addressed.
Academic Editors: Jonathan Iredell and Sally Partridge
Received: 2 July 2015 / Revised: 4 September 2015 / Accepted: 8 October 2015 / Published: 21 October 2015
(This article belongs to the Special Issue Antibiotic Resistance: Mobility and Microbiomes)
View Full-Text   |   Download PDF [1053 KB, uploaded 21 October 2015]   |  

Abstract

Variations in porin proteins are common in Gram-negative pathogens. Altered or absent porins reduce access of polar antibiotics across the outer membrane and can thus contribute to antibiotic resistance. Reduced permeability has a cost however, in lowering access to nutrients. This trade-off between permeability and nutritional competence is the source of considerable natural variation in porin gate-keeping. Mutational changes in this trade-off are frequently selected, so susceptibility to detergents and antibiotics is polymorphic in environmental isolates as well as pathogens. Understanding the mechanism, costs and heterogeneity of antibiotic exclusion by porins will be crucial in combating Gram negative infections. View Full-Text
Keywords: bacterial diversity; trade-offs; nutrient uptake; outer membranes; antibiotic susceptibility bacterial diversity; trade-offs; nutrient uptake; outer membranes; antibiotic susceptibility
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Ferenci, T.; Phan, K. How Porin Heterogeneity and Trade-Offs Affect the Antibiotic Susceptibility of Gram-Negative Bacteria. Genes 2015, 6, 1113-1124.

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